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A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-017)
Sponsor: Merck Sharp & Dohme LLC
Summary
Researchers have designed a study medicine called opevesostat as a new way to treat prostate cancer. The purpose of this study is to learn what happens to opevesostat in a person's body over time (a pharmacokinetic or PK study). Researchers will compare what happens to opevesostat in the body when it is given with and without another medicine called itraconazole.
Official title: A Phase 1, Open-Label, Fixed-Sequence Study to Evaluate the Effects of Multiple Doses of Itraconazole on the Single-Dose Pharmacokinetics of MK-5684 in Healthy Adult Male Participants
Key Details
Gender
MALE
Age Range
19 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
14
Start Date
2026-05-11
Completion Date
2026-06-14
Last Updated
2026-06-12
Healthy Volunteers
Yes
Conditions
Interventions
Opevesostat
Administered via oral film-coated tablet
Prednisone
Administered via oral tablet
Fludrocortisone acetate
Administered via oral tablet
Itraconazole
Administered via oral capsule
Locations (1)
Celerion, Inc. ( Site 0001)
Lincoln, Nebraska, United States