Clinical Research Directory
Browse clinical research sites, groups, and studies.
Comparative Study of Microneedling With Topical Minoxidil 5% ± NB-UVB in Stable Vitiligo"
Sponsor: Sohag University
Summary
This study is a randomized controlled trial comparing microneedling with topical minoxidil 5% versus microneedling with minoxidil combined with NB-UVB phototherapy in stable vitiligo. It aims to evaluate both clinical and histopathological outcomes in 30 patients with non-segmental stable vitiligo. Vitiligo is a chronic depigmenting disorder caused by melanocyte destruction with significant psychosocial impact. The study also investigates immunohistochemical changes, particularly Wnt/β-catenin signaling expression in lesional skin. The combination therapy is expected to enhance repigmentation by improving melanocyte activation, drug delivery, and angiogenesis
Official title: Comparative Clinical and Histopathological Study of Microneedling With Topical Minoxidil 5% Versus Microneedling With Topical Minoxidil 5% Combined With Narrow-Band Ultraviolet B Phototherapy in the Treatment of Stable Vitiligo
Key Details
Gender
All
Age Range
16 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-05-20
Completion Date
2027-10-15
Last Updated
2026-04-29
Healthy Volunteers
Yes
Conditions
Interventions
microneedling with minoxidil 5% and NBUVB
Micronnedlin depth 1% then topical Minoxidil5% and Narrow Band UVB
Microneedling with Minoxidil5%
Microneedling with topical Minoxidil 5%