Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Sponsor: EMD Serono Research & Development Institute, Inc.
Summary
This study aims to address the unmet medical need of participants with metastatic colorectal cancer (mCRC) who have previously been treated with irinotecan, oxaliplatin, a fluoropyrimidine, and bevacizumab, by demonstrating an overall survival prolongation with precemtabart tocentecan (Precem-TcT) as single agent or Precem-TcT in combination with bevacizumab compared to trifluoride/tipiracil (FTD-TPI) plus bevacizumab.
Official title: A Randomized, Open Label, 3-arm Phase 3 Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1020
Start Date
2026-05-06
Completion Date
2029-10-16
Last Updated
2026-09-09
Healthy Volunteers
No
Conditions
Interventions
Precemtabart tocentecan
Precem-TcT, administered, once every 3 weeks intravenously, on Day 1 of each 21-day cycle.
Bevacizumab
Bevacizumab, administered intravenously every 3 weeks on Day 1 of each 21-day cycle or every 2 weeks on Day 1 and Day 15 of each 28-day cycle.
Trifluridine/Tipiracil (FTD-TPI)
FTD-TPI, tablet, administered orally twice daily, on Days 1 to 5 and Days 8 to 12 of each 28-day cycle.
Locations (66)
Rocky Mountain Cancer Centers, LLP- Aurora
Lone Tree, Colorado, United States
Florida Cancer Specialists-Broadway
Fort Myers, Florida, United States
Florida Cancer Specialists - St. Petersburg Bayfront
St. Petersburg, Florida, United States
Florida Cancer Specialists East - FCS EAST - West Palm Beach
West Palm Beach, Florida, United States
Illinois Cancer Specialists
Arlington Heights, Illinois, United States
Illinois CancerCare PC
Peoria, Illinois, United States
Springfield Clinic
Springfield, Illinois, United States
Profound Research LLC at Cancer and Leukemia Center
Sterling Heights, Michigan, United States
Minnesota Oncology Hematology, P.A.
Saint Louis Park, Minnesota, United States
Missouri Cancer Associates - 150518964
Columbia, Missouri, United States
White Plains Hospital Medical and Wellness PRIME
White Plains, New York, United States
SCRI Oncology Partners
Nashville, Tennessee, United States
Texas Oncology, P.A. - Abilene - 300210366
Abilene, Texas, United States
Texas Oncology-South Austin
Austin, Texas, United States
Texas Oncology DFW
Bedford, Texas, United States
Texas Oncology- San Antonio
San Antonio, Texas, United States
Texas Oncology, P.A. - Tyler
Tyler, Texas, United States
Virginia Oncology Associates
Newport News, Virginia, United States
Blue Ridge Cancer Care - 300202915
Roanoke, Virginia, United States
Instituto de Oncologia de Rosario
Rosario, Santa Fe Province, Argentina
Investigaciones Clinicas Moleculares ICM
Ciudad Autonoma Buenos Aires, Argentina
Centro Oncologico de Excelencia
San Juan, Argentina
Centro de Investigaciones Medicas Tucuman
San Miguel de Tucumán, Argentina
GenesisCare North Shore (Oncology)
St Leonards, New South Wales, Australia
Icon Cancer Centre Chermside
Chermside, Queensland, Australia
Mater Misericordiae Ltd - PARENT
South Brisbane, Queensland, Australia
Flinders Medical Centre
Bedford Park, South Australia, Australia
LKH - Universitätsklinikum der PMU Salzburg - Innere Med III/Hämatologie und Onkologie
Salzburg, Austria
Cliniques Universitaires Saint-Luc - STL
Brussels, Belgium
Grand Hospital de Charleroi - PARENT
Charleroi, Belgium
The Ottawa Hospital Cancer Centre
Ottawa, Ontario, Canada
University Health Network - Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
Guangxi Medical University Cancer Hospital
Nanning, Guangxi Zhuang, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, China
Jiangsu Province Hospital
Nanjing, Jiangsu, China
Sichuan Cancer Hospital
Chengdu, Sichuan, China
The Second Affiliated Hospital of Zhejiang University School of Medicine - 300173725
Hangzhou, Zhejiang, China
Hopital Claude Huriez - CHU Lille - service d'oncologie medicale
Lille, Nord, France
CHU Saint Etienne - Hôpital Nord - Service de Gastro-Entérologie et Hépatologie
Saint Priest En Jarez, Pays de la Loire Region, France
Centre Leon Berard - Service d'Oncologie Medicale
Lyon, Rhone, France
Groupe Hospitalier Pitie-Salpetriere - Service Hépato-Gastro-Entérologie
Paris, France
Krankenhaus Nordwest GmbH - Neurologische Klinik
Frankfurt am Main, Hesse, Germany
The Chinese University of Hong Kong (CUHK) - Prince of Wales Hospital (PWH)
Hong Kong, Hong Kong
NHO Kyushu Cancer Center - 300175822
Fukuoka, Fukuoka, Japan
Kanagawa Cancer Center - Dept of Gastroenterology
Yokohama, Kanagawa, Japan
Kindai University Hospital
Sakai-shi, Osaka, Japan
Saitama Cancer Center - 300175812
Kitaadachi-gun, Saitama, Japan
National Cancer Center Hospital
Chūōku, Tokyo-To, Japan
Cancer Institute Hospital of JFCR
Kōtoku, Tokyo-To, Japan
SP ZOZ Szpital Uniwersytecki w Krakowie - Dept of Clinical Oncology and Oncology Clinic
Krakow, Poland
National Cancer Center
Goyang-si, Gyeonggi-do, South Korea
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
Kyungpook National University Chilgok Hospital
Daegu, Gyeongsangnam-do, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital, Yonsei University Health System - Division of Infectious Diseases
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
The Catholic University of Korea, Seoul St. Maryâ
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Hospital Universitario Ramon y Cajal - Servicio de Oncologia
Madrid, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
China Medical University Hospital
Taichung, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Aberdeen Royal Infirmary - Dept of Oncology
Aberdeen, Grampian Region, United Kingdom
The Christie Hospital - Dept of Oncology
Manchester, Great Manchester, United Kingdom