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Restricted Fluid Therapy for Newborn Breathing Problems
Sponsor: Hitit University
Summary
Evidence suggests that increased intravascular and interstitial fluid load in neonates with transient tachypnea of the newborn (TTN) may delay the clearance of fetal alveolar fluid (FAF). Restricted fluid (RF) therapy may accelerated FAF clearance and improve outcomes in these infants. Term and late preterm infants with TTN requiring nasal intermittent positive pressure ventilation (NIPPV) were randomized within first 2 hours after birth to receive either RF or standard fluid (SF) therapy. Primary outcomes were the duration of NIPPV and the day of discharge. Secondary outcomes included changes in weight, urine output, biochemical parameters, and monitoring of potential adverse effects.
Official title: Eficacy and Safety of Restricted Fluid Therapy in Transient Tachypnea of the Newborn: A Randomized Controlled Study
Key Details
Gender
All
Age Range
34 Weeks - 42 Weeks
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2021-10-01
Completion Date
2023-07-31
Last Updated
2026-04-24
Healthy Volunteers
No
Interventions
restricted fluid regimen
The total fluid volume administered on the first day was initiated at 50 mL/kg/day in the RF group for infants with a gestational age of 34⁰/₇-36⁶/₇ weeks. 40 mL/kg/day in gestational age of ≥37 weeks
Standart fluid
70 mL/kg/day in the standart fluid group for infants with a gestational age of 34⁰/₇-36⁶/₇ weeks, whereas it was initiated at 60 mL/kg/day in thestandart fluid group for infants with a gestational age of ≥37 weeks.
Locations (1)
Hitit University Erol Olçok Training and Research Hospital
Çorum, Çorum, Turkey (Türkiye)