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Digital Telecytology for Triage of HPV-Positive Women in Cameroon
Sponsor: University Hospital, Geneva
Summary
This study evaluates the diagnostic accuracy and feasibility of a same-day cervical cancer screening strategy using HPV self-sampling followed by digital telecytology triage among HPV-positive women in Cameroon. Women aged 30-49 years (or 25-49 years if HIV-positive) will undergo primary HPV testing using the GeneXpert system. HPV-positive women will be managed according to an extended HPV genotyping-based algorithm, including immediate treatment, telecytology triage, or follow-up. Histological assessment serves as the reference standard for the detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Secondary objectives include evaluation of AI-assisted telecytology and visual inspection with acetic acid (VIA), as well as the acceptability of screening and treatment strategies among women and healthcare providers. The study aims to generate evidence to support scalable, WHO-recommended test-triage-treat approaches in low-resource settings
Official title: Evaluation of Digital Cytology for the Triage of HPV-positive Women in a Same-day "Test-triage-treat" Cervical Cancer Screening Strategy in Cameroon
Key Details
Gender
FEMALE
Age Range
25 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
1800
Start Date
2025-09-08
Completion Date
2027-09-08
Last Updated
2026-04-24
Healthy Volunteers
Yes
Conditions
Interventions
HPV testing (self-sampling)
HPV testing performed on self-collected vaginal samples providing extended genotyping for high-risk HPV types.
Digital telecytology
Digital cytology performed on HPV-positive women, including slide preparation, digitization, and remote interpretation by trained cytology experts for the detection of cytological abnormalities (≥ ASC-US).
AI-assisted telecytology
Artificial intelligence-assisted analysis of digital cytology images to support detection of cervical abnormalities in HPV-positive women.
Thermal ablation
Thermal ablation is used for treatment of women who are HPV16-positive, as well as for women positive for HPV types 18, 31, 33, 35, 45, 52, or 58 who have abnormal cytology results (≥ ASC-US).
Locations (2)
Centre Hospitalier Universitaire de Yaoundé
Yaoundé, Cameroon
Yaoundé University Teaching Hospital (CHU)
Yaoundé, Cameroon