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RECRUITING
NCT07550023
NA

Effects Of Dietary Fats on Gut Microbiota Composition and Metabolic Activity in Healthy Adults

Sponsor: University of Glasgow

View on ClinicalTrials.gov

Summary

This study will investigate how adding a specific type of dietary fat to daily meals for two weeks affects the gut bacteria and their activity. Participants will be randomly assigned to consume one of four types of fat: butter, coconut oil, olive oil, or sunflower oil (60 mL each day for 2 weeks). Stool and blood samples (after an overnight fast) will be collected at 3 time points during the study (Days 1, 7, and 22). These samples will be used to measure metabolites produced by gut bacteria, the types of bacteria present in the gut, blood lipids, and inflammatory markers. The study, based on previous in vitro findings, aims to understand whether different types of fats (based on their structure and level of saturation) have different effects on gut bacteria and their activity in healthy subjects.

Key Details

Gender

All

Age Range

20 Years - 50 Years

Study Type

INTERVENTIONAL

Enrollment

64

Start Date

2026-03-23

Completion Date

2028-03-31

Last Updated

2026-04-24

Healthy Volunteers

Yes

Interventions

OTHER

Butter

Participants will consume approximately 65 g/day of butter as their primary dietary fat for 14 days, replacing most habitual dietary fat intake.

OTHER

Coconut oil

Participants will consume approximately 55 g/day of coconut oil as their primary dietary fat for 14 days, replacing most habitual dietary fat intake.

OTHER

Extra Virgin Olive Oil

Participants will consume 60 mL/day of olive oil as their primary dietary fat for 14 days, replacing most habitual dietary fat intake.

OTHER

Sunflower Oil

Participants will consume 60 mL/day of sunflower oil as their primary dietary fat for 14 days, replacing most habitual dietary fat intake.

Locations (1)

New Lister Building, Glasgow Royal Infirmary, 10-16 Alexandra Parade, G31 2ER

Glasgow, United Kingdom