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NOT YET RECRUITING
NCT07550621
PHASE1

Drug-Drug Interaction Study of MDR-001 With Rifampin and Itraconazole in Healthy Adult Participants

Sponsor: MindRank AI Ltd

View on ClinicalTrials.gov

Summary

A Phase I, open-label, fixed-sequence, two-part drug-drug interaction study in healthy Chinese adults to evaluate the effect of multiple-dose rifampin (Part A) or itraconazole (Part B) on the single-dose pharmacokinetics of MDR-001, an oral GLP-1 receptor agonist.

Official title: A Phase 1 Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of MDR-001 and the Effect of Itraconazole on the Pharmacokinetics of MDR-001 in Healthy Adult Study Participants

Key Details

Gender

All

Age Range

18 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

28

Start Date

2026-05-06

Completion Date

2026-06-08

Last Updated

2026-04-24

Healthy Volunteers

Yes

Interventions

DRUG

MDR-001

Oral small-molecule GLP-1 receptor agonist ;Investigational drug (not yet approved)

DRUG

Rifampin

Strong CYP3A4 inducer; Marketed anti-tuberculosis drug

DRUG

Itraconazole

Strong CYP3A4 inhibitor; Marketed antifungal drug

Locations (1)

The First Hospital of Jilin University

Changchun, Jilin, China