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Contrast-Induced Acute Kidney Injury Prevention in Acute Heart Failure
Sponsor: Jin Joo Park
Summary
The K-PROSE study is a randomized clinical investigation evaluating strategies to prevent contrast-induced acute kidney injury (CI-AKI) in patients hospitalized with acute heart failure and moderate renal dysfunction (eGFR 30-75 mL/min/1.73 m²). Patients requiring contrast-enhanced CT imaging are randomized to either standard intravenous saline hydration or a furosemide-based decongestion strategy. Renal function is assessed using serial measurements of creatinine and cystatin C, before and after contrast exposure. By comparing renal outcomes, congestion status, and safety profiles, this study aims to determine whether a decongestion-focused approach provides superior renal protection compared with conventional hydration in high-risk acute heart failure patients.
Official title: Contrast-Induced Acute Kidney Injury in Acute Heart Failure With Renal Dysfunction: The Kidney Protection Strategies Evaluation in Acute Heart Failure (K-PROSE)
Key Details
Gender
All
Age Range
20 Years - Any
Study Type
INTERVENTIONAL
Enrollment
190
Start Date
2026-07-01
Completion Date
2027-06-30
Last Updated
2026-07-16
Healthy Volunteers
No
Conditions
Interventions
Furosemide
Intravenous furosemide administered to promote diuresis as part of a decongestion-based renal protection strategy.
0.9 % Normal Saline
Intravenous isotonic saline administered as standard hydration for the prevention of contrast-induced acute kidney injury.
Locations (1)
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea