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Lymphocyte Subpopulations in Peripheral Giant Cell Granuloma
Sponsor: Ataturk University
Summary
Peripheral giant cell granuloma (PGCG) is a non-neoplastic inflammatory lesion of gingival tissues. This study aims to evaluate and compare lymphocyte subpopulations in PGCG tissues and adjacent healthy gingival tissues obtained from the same individuals. A total of 28 systemically healthy, non-smoking patients diagnosed with PGCG are included in this study. Biopsy samples are collected during surgical excision of PGCG lesions, and corresponding healthy gingival tissues are obtained from the same patients. Immunohistochemical analysis is performed to assess lymphocyte subpopulations, including CD3, CD4, CD8, CD20, and CD79a. The proportions of these cells are compared between diseased and healthy tissues.
Official title: Immunohistochemical Evaluation of Lymphocyte Subpopulations in Peripheral Giant Cell Granuloma and Healthy Gingival Tissues: A Within-Subject Controlled Study
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
28
Start Date
2026-01-01
Completion Date
2026-03-30
Last Updated
2026-04-24
Healthy Volunteers
No
Interventions
Immunohistochemical Analysis
Immunohistochemical staining is performed on gingival tissue samples to evaluate lymphocyte subpopulations, including CD3, CD4, CD8, CD20, and CD79a. The proportion of positively stained cells is determined by calculating the percentage of positive cells relative to the total number of counted cells.
Locations (1)
Ataturk University Faculty of Dentistry
Erzurum, Malatya, Turkey (Türkiye)