Clinical Research Directory

Inclusion Criteria: 1. Diagnosed with atherosclerotic cardiovascular disease (ASCVD), and the course of the disease exceeds 3 months 2. The body mass index (BMI) at the time of screening was ≥24.0 kg/m ². Patients with type 2 diabetes have a BMI of ≥22.0 kg/m ² Exclusion Criteria: 1. Screening for myocardial infarction, acute decompensated heart failure, hospitalization due to heart failure, unstable angina pectoris, stroke or transient ischemic attack, coronary revascularization, atrial flutter/fibrillation ablation, valve repair/replacement, carotid or peripheral artery recanalization within 30 days prior to the screening 2. Severe hypoglycemic events or recurrent hypoglycemic events occurred within one month before screening 3. When screening, there are proliferative retinopathy or macular degeneration requiring acute treatment, painful diabetic neuropathy, diabetic foot ulcers, and intermittent claudication 4. Coronary revascularization, atrial flutter/fibrillation ablation, valve repair/replacement, and carotid or peripheral artery recanalization are planned to be performed during the trial 5. Those with a history of acute or chronic pancreatitis, acute cholecystitis, or symptomatic or treatment-requiring gallbladder diseases 6. Any malignant tumor of the organ system has occurred within the past five years, regardless of whether there is evidence of local recurrence or metastasis, except for cured local cutaneous basal cell carcinoma and cervical carcinoma in situ 7. Pregnant or lactating women, or participants with fertility who are unwilling to take effective contraceptive measures 8. Those who have had any previous conditions that affected gastric emptying or have undergone gastrointestinal surgery 9. Diagnosed or suspected as type 1 diabetes, special type diabetes or secondary diabetes 10. Acute complications of diabetes occurred within one month before screening 11. There are endocrine diseases that may significantly affect weight