Clinical Research Directory

Inclusion Criteria: 1. Healthy male and female subjects (with no specific repartition) 2. Subjects of Caucasian ethnicity 3. Subjects aged between 18 and 65 years (extremes included) 4. Subjects clinically showing moderate gums inflammation (gingivitis grade II, in particular all gingival scores for the mean should be between 1.75 and 2.3, according to Löe and Silness gingival scoring system), in particular: 1. 20% of the subjects with localized gingivitis (10-30% of evaluated sites with bleeding) 2. 80% of them with generalized gingivitis (\>30% of evaluated sites with bleeding) 5. Subjects with dental plaque (total plaque score at inclusion ≥2) 6. Subjects registered with the national health service 7. Subjects certifying the truthfulness of the personal data disclosed to the Principal Investigator or designated personnel 8. Subjects able to understand the language used in the investigation centre and the information given by the Principal Investigator or designated personnel 9. Subjects able to respect the instructions given by the Principal Investigator or designated personnel as well as able to respect the study constraints and specific requirements 10. Subjects who commit not to change their daily routine or lifestyle during the study 11. Subjects on stable pharmacological therapy (except for the pharmacological therapy in the non-inclusion criteria) for at least one month without any changes expected or planned during the study 12. Subjects informed about the test procedures who have signed a consent form and privacy agreement Exclusion Criteria: 1. Subjects who do not meet the inclusion criteria 2. Smokers subjects 3. Subjects planning toothcare during the study period 4. Subjects using dental apparatus or using dental prosthesis, with generalized tooth recession, with presence of caries, with dental abscess or signs of periodontitis (periodontal probing depth \>3mm) or active periodontitis 5. Subjects using other dental hygiene products than provided (e.g. dental floss, interdental brushes, mouthwash, etc) during the study period 6. Subjects with any acute, chronic, or progressive disease or condition that may interfere with the study data or that the Principal Investigator considers dangerous to the subject or incompatible with the requirements of the study 7. Subjects participating or planning to participate in other clinical trials 8. Subjects who participated in a similar study without respecting an adequate washout period (at least one month) 9. Subjects that have intolerances or allergies to ingredients of the study product Page 8 of 28 Clinical Study Protocol: EC\_0000149/2026 of 13/03/2026 10. Subjects under pharmacological treatments that are considered incompatible with the study requirement by the Principal Investigator 11. Subjects who are currently using products with the same activity as the study product, or who haven't observed an adequate washout period (at least one month) 12. Subjects admitted to a health or social facility 13. Subjects planning a hospitalization during the study 14. Subjects not able to be contacted in case of emergency 15. Subjects deprived of freedom by administrative or legal decision or under guardianship 16. Subjects who have or have had a history of alcohol or drug addiction 17. Subjects with eating disorders (i.e. bulimia, psychogenic eating disorders, etc.) 18. Subject breastfeeding, pregnant or not willing to take necessary precautions to avoid pregnancy during the study (for the women of childbearing potential).