Clinical Research Directory

Inclusion Criteria: 1. Aged 30 to 80 years 2. Patients with unilateral upper limb motor dysfunction caused by primary ischemic/hemorrhagic stroke within 1 to 6 months prior to enrollment 3. Cerebral magnetic resonance diffusion-weighted imaging (DWI) at the time of onset indicating that the stroke lesion is limited to the unilateral basal ganglia region 4. Modified Rankin Scale (mRS) score of 0 to 2 before stroke onset 5. Fugl-Meyer Motor Function Assessment of Upper Extremities (FMA-UE) score of 10 to 42 6. Montreal Cognitive Assessment (MoCA) score \> 18 7. Fugl-Meyer Balance Assessment score \> 6 8. Normal binocular visual acuity or corrected visual acuity 9. Normal hearing and intact verbal comprehension ability 10. Provided written informed consent Exclusion Criteria: 1. Patients with other severe cardiovascular and cerebrovascular diseases and unstable vital signs 2. Patients with motor dysfunction caused by other etiologies, such as amyotrophic lateral sclerosis, myasthenia gravis, muscular dystrophy, hypokalemic periodic paralysis, spondylitis, arthritis, osteomyelitis, etc. 3. Patients with severe diseases of the lungs, liver, kidneys and other vital organs 4. Patients with limb movement impairment caused by diseases such as fractures and arthritis 5. Modified Ashworth Scale (MAS) score \> 3 6. Patients unable to understand and cooperate with limb rehabilitation training due to factors such as severe aphasia 7. Presence of severe visual field defects or visual impairments (e.g., hemianopsia, hemispatial neglect, etc. 8. History of previous stroke 9. A history of severe motor injury and/or surgical intervention of the affected upper limb, such as muscle tear, tendon rupture, rhabdomyolysis 10. Life expectancy of less than 1 year due to the underlying disease 11. Undergoing major surgery within the past 30 days or planning to undergo major surgery within the next 90 days 12. Pregnant or lactating women 13. History of drug or alcohol abuse, head trauma or central nervous system infection; current use of cognition-impairing medications such as psychoactive or sedative drugs 14. With definite psychiatric and psychological disorders, such as depression, anxiety disorder, obsessive-compulsive disorder, schizophrenia, autism, chronic sleep disorder, consciousness disorder, etc. 15. Having implanted electronic devices in the body that interfere with magnetic resonance imaging (MRI), such as cochlear implants, cardiac pacemakers/defibrillators, drug delivery pumps 16. Poor compliance of the subject, their family members and caregivers, or inability to complete at least 12 months of follow-up as required by the study 17. Having been enrolled in other clinical studies that conflict with this study 18. Judged by the Indication Evaluation Committee as ineligible for or not falling within the scope of this study.