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ALTO-207 in Adults With Treatment-resistant Depression (TRD)
Sponsor: Alto Neuroscience
Summary
The purpose of this trial is to measure depressive symptoms following treatment with ALTO-207 compared with placebo in participants with TRD.
Official title: A Randomized, Double-blind, Placebo-controlled Trial of ALTO-207 in Adults With Treatment-resistant Depression
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
178
Start Date
2026-05
Completion Date
2027-12
Last Updated
2026-04-28
Healthy Volunteers
No
Conditions
Interventions
ALTO-207
ALTO-207 BID
Placebo
Matching Placebo
Locations (48)
Site 7074
Birmingham, Alabama, United States
Site 7173
Dothan, Alabama, United States
Site 7000
Phoenix, Arizona, United States
Site 7153
Chino, California, United States
Site 7156
Oakland, California, United States
Site 7082
Oceanside, California, United States
Site 7159
Palo Alto, California, United States
Site 7016
Sacramento, California, United States
Site 7144
San Diego, California, United States
Site 7171
Valley Village, California, United States
Site 7152
Saint Augustine, Florida, United States
Site 7148
Albany, Georgia, United States
Site 7146
Atlanta, Georgia, United States
Site 7064
Peachtree Corners, Georgia, United States
Site 7141
Savannah, Georgia, United States
Site 7169
Indianapolis, Indiana, United States
Site 7151
Annapolis, Maryland, United States
Site 7054
Pikesville, Maryland, United States
Site 7166
Worcester, Massachusetts, United States
Site 7155
Ann Arbor, Michigan, United States
Site 7154
Bloomfield Hills, Michigan, United States
Site 7170
Amherst, New York, United States
Site 7055
Cedarhurst, New York, United States
Site 7162
Lewiston, New York, United States
Site 7157
Syracuse, New York, United States
Site 7143
Charlotte, North Carolina, United States
Site 7029
Cincinnati, Ohio, United States
Site 7158
Garfield Heights, Ohio, United States
Site 7172
East Providence, Rhode Island, United States
Site 7176
Dallas, Texas, United States
Site 7160
Fort Worth, Texas, United States
Site 7150
Galveston, Texas, United States
Site 7175
Houston, Texas, United States
Site 7145
Houston, Texas, United States
Site 7161
Irving, Texas, United States
Site 7177
Fairfax, Virginia, United States
Site 7128
Seattle, Washington, United States
Site 7163
South Charleston, West Virginia, United States
Site 7419
Antrim, United Kingdom
Site 7411
Birmingham, United Kingdom
Site 7414
Bristol, United Kingdom
Site 7412
Cardiff, United Kingdom
Site 7418
Exeter, United Kingdom
Site 7415
London, United Kingdom
Site 7413
Nottingham, United Kingdom
Site 7410
Oxford, United Kingdom
Site 7402
Prescot, United Kingdom
Site 7416
Sheffield, United Kingdom