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Home-Based Respiratory Muscle Training and Aerobic Exercise Programs to Improve Lung Health in Current and Former Cigarette Smokers
Sponsor: Roswell Park Cancer Institute
Summary
This clinical trial studies whether home-based respiratory muscle training (RMT) and aerobic exercise (AE) programs can be used to improve lung health in current and former cigarette smokers. Lung cancer, the leading cause of cancer death, is overwhelmingly caused by exposure to cigarette smoke. Research suggests that daily activity reduces lung cancer risk in current and former smokers. However, current and former smokers are generally not active and new approaches to improve lung health are needed. During the home-based RMT program, participants use a handheld device to complete breathing exercise sessions consisting of breathing in and out against adjustable resistance. During the home-based AE program, participants complete aerobic exercises using a stationary bike working at a moderate workload against adjustable resistance. The home-based RMT and AE programs may be effective ways to strengthen the breathing muscles, which may improve lung health in current and former cigarette smokers.
Official title: Effects of Respiratory Muscle Training and Aerobic Exercise on Lung Health in Smokers: A Pilot Parallel-Group Study for Lung Cancer Prevention
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2026-09-15
Completion Date
2029-05-01
Last Updated
2026-08-21
Healthy Volunteers
Yes
Conditions
Interventions
Accelerometry
Ancillary studies
Aerobic Exercise
Complete tailored intensity AE cycling sessions
Biospecimen Collection
Undergo blood, nasal swab, exhaled breath, and urine sample collection
Educational Intervention
Receive AE and RMT education
Electronic Health Record Review
Ancillary studies
Physical Performance Testing
Ancillary studies
Respiratory Muscle Training
Complete RMT sessions
Supportive Care
Receive virtually supervised session/call
Survey Administration
Ancillary studies
Locations (1)
Roswell Park Cancer Institute
Buffalo, New York, United States