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NOT YET RECRUITING
NCT07553819
NA

Home-Based Respiratory Muscle Training and Aerobic Exercise Programs to Improve Lung Health in Current and Former Cigarette Smokers

Sponsor: Roswell Park Cancer Institute

View on ClinicalTrials.gov

Summary

This clinical trial studies whether home-based respiratory muscle training (RMT) and aerobic exercise (AE) programs can be used to improve lung health in current and former cigarette smokers. Lung cancer, the leading cause of cancer death, is overwhelmingly caused by exposure to cigarette smoke. Research suggests that daily activity reduces lung cancer risk in current and former smokers. However, current and former smokers are generally not active and new approaches to improve lung health are needed. During the home-based RMT program, participants use a handheld device to complete breathing exercise sessions consisting of breathing in and out against adjustable resistance. During the home-based AE program, participants complete aerobic exercises using a stationary bike working at a moderate workload against adjustable resistance. The home-based RMT and AE programs may be effective ways to strengthen the breathing muscles, which may improve lung health in current and former cigarette smokers.

Official title: Effects of Respiratory Muscle Training and Aerobic Exercise on Lung Health in Smokers: A Pilot Parallel-Group Study for Lung Cancer Prevention

Key Details

Gender

All

Age Range

50 Years - Any

Study Type

INTERVENTIONAL

Enrollment

200

Start Date

2026-09-15

Completion Date

2029-05-01

Last Updated

2026-08-21

Healthy Volunteers

Yes

Conditions

Interventions

PROCEDURE

Accelerometry

Ancillary studies

OTHER

Aerobic Exercise

Complete tailored intensity AE cycling sessions

PROCEDURE

Biospecimen Collection

Undergo blood, nasal swab, exhaled breath, and urine sample collection

OTHER

Educational Intervention

Receive AE and RMT education

OTHER

Electronic Health Record Review

Ancillary studies

OTHER

Physical Performance Testing

Ancillary studies

PROCEDURE

Respiratory Muscle Training

Complete RMT sessions

OTHER

Supportive Care

Receive virtually supervised session/call

OTHER

Survey Administration

Ancillary studies

Locations (1)

Roswell Park Cancer Institute

Buffalo, New York, United States