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RECRUITING
NCT07553845

A Multimodal Prospective Cohort Study of Parkinsonism

Sponsor: Ruijin Hospital

View on ClinicalTrials.gov

Summary

This is a single-center, prospective, observational cohort study designed to investigate the progression and differential diagnosis of Parkinsonism using a multimodal approach. The study plans to enroll 400 patients with Parkinsonism, 120 patients with rapid eye movement sleep behavior disorder, and 120 healthy controls, with follow-up for 5 years. Assessments will include neuroimaging, clinical rating scales, biological samples, blood flow evaluation, neurophysiological testing, tremor analysis, and voice and video assessments. The study aims to characterize disease progression, explore factors associated with progression from rapid eye movement sleep behavior disorder to Parkinsonism, and improve the ability to distinguish among different Parkinsonian disorders.

Key Details

Gender

All

Age Range

31 Years - 79 Years

Study Type

OBSERVATIONAL

Enrollment

640

Start Date

2024-05-01

Completion Date

2029-05

Last Updated

2026-04-28

Healthy Volunteers

Yes

Locations (1)

Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, China