Clinical Research Directory

Inclusion Criteria: * Neonates diagnosed with hypoxic-ischemic encephalopathy (HIE) at the Neonatal Center, National Children's Hospital * Gestational age ≥ 36 weeks * Assessed using the modified Sarnat staging within the first 0-6 hours after birth * Eligible for and/or treated with therapeutic hypothermia according to institutional protocol * Underwent clinical and paraclinical monitoring during hospitalization * Received brain magnetic resonance imaging (MRI) during the neonatal period (from 5 to 17 days of age) * Availability of complete medical records for data collection and analysis Exclusion Criteria: * Presence of major congenital anomalies, particularly involving the central nervous system * Absence of brain MRI during the study period * Refusal of participation by parent(s) or legal guardian(s)