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Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma
Sponsor: Hoffmann-La Roche
Summary
The purpose of this study is to assess the efficacy and safety of cevostamab in combination with pomalidomide and dexamethasone (CevosPd) versus standard of care (SOC) in participants with multiple myeloma (MM) who have received one to three prior lines of therapy and have been exposed to an anti-CD38 monoclonal antibody (mAb) and lenalidomide.
Official title: A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Patients With Multiple Myeloma Who Have Received One to Three Prior Lines of Therapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
380
Start Date
2026-06-23
Completion Date
2033-01-31
Last Updated
2026-09-11
Healthy Volunteers
No
Conditions
Interventions
Cevostamab
Participants will receive cevostamab IV as per the schedule given in the protocol.
Pomalidomide
Participants will receive pomalidomide tablet orally PO as per the schedule given in the protocol.
Dexamethasone
Participants will receive dexamethasone tablet orally PO or IV as per the schedule given in the protocol.
Daratumumab
Participants will receive daratumumab SC as per the schedule given in the protocol.
Elotuzumab
Participants will receive elotuzumab IV as per the schedule given in the protocol.
Carfilzomib
Participants will receive carfilzomib IV as per the schedule given in the protocol.
Locations (75)
City of Hope National Medical Center
Duarte, California, United States
City of Hope - Lennar Foundation Cancer Center
Irvine, California, United States
Yale University
New Haven, Connecticut, United States
MedStar Washington Hospital Center MedStar Georgetown Cancer Institute
Washington D.C., District of Columbia, United States
Emory University Hospital Midtown
Atlanta, Georgia, United States
Novant Health Cancer Institute
Charlotte, North Carolina, United States
Forsythe Memorial Hospital Inc., dba Novant Health Oncology Specialists
Winston-Salem, North Carolina, United States
TriHealth Cancer and Blood Institute
Cincinnati, Ohio, United States
West Virginia University
Morgantown, West Virginia, United States
St Vincent's Hospital Melbourne
Fitzroy, Victoria, Australia
Hospital Israelita Albert Einstein
São Paulo, São Paulo, Brazil
Hamilton Health Sciences - Juravinski Cancer Centre
Hamilton, Ontario, Canada
Sun yat-sen University Cancer Center
Guangzhou, Guangdong, China
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China
The Affiliated Hospital Of Qingdao University
Qingdao, Shandong, China
The First Affilliated Hospital of Kunming Medical University
Kunming, Yunnan, China
The First Affiliated Hospital, Zhejiang University School of Medicine - Qingchun Campus - PPDS
Hangzhou, Zhejiang, China
Nanfang Hospital, Southern Medical University
Guangzhou, China
Qilu Hospital of Shandong University
Jinan, China
The First Affiliate Hospital of Guangxi Medical University
Nanning, China
Zhongshan Hospital Fudan University
Shanghai, China
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, China
The First Affiliated Hospital of Soochow University
Suzhou, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, China
Fakultni nemocnice Hradec Kralove
Hradec Králové, Czechia
Fakultni nemocnice Ostrava
Ostrava, Czechia
Aarhus Universitetshospital
Aarhus, Denmark
Sygehus Lillebælt, Vejle;Hæmatologisk Forskningsenhed, HKFE
Vejle, Denmark
HELIOS Klinikum Bad Saarow
Bad Saarow, Germany
Vivantes Klinikum Am Urban Klinik für Innere Medizin Hämatologie und Onkologie
Berlin, Germany
Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin
Berlin, Germany
Marien-Hospital Klinik f.Hämatologie Onkologie u.Palliativmedizin
Düsseldorf, Germany
Universitätsklinikum Frankfurt
Frankfurt, Germany
Universitätsmedizin Greifswald
Greifswald, Germany
UKSH, Campus Kiel
Kiel, Germany
Evangelismos General Hospital of Athens
Athens, Greece
Alexandras General Hospital of Athens
Athens, Greece
Anticancer Hospital of Thessaloniki " Theagenio"
Thessaloniki, Greece
Rambam Health Care Campus
Haifa, Israel
Hadassah Ein Karem Hospital
Jerusalem, Israel
Chaim Sheba Medical Center
Ramat Gan, Israel
Ichilov Sourasky Medical Center
Tel Aviv, Israel
IRCCS Istituto Romagnolo per lo studio dei tumori "Dino Amadori"
Meldola, Emilia-Romagna, Italy
Asst Papa Giovanni Xxiii
Bergamo, Lombardy, Italy
Istituto Clinico Humanitas
Rozzano, Lombardy, Italy
Toyohashi Municipal Hospital
Toyohashi, Aichi-ken, Japan
Nagoya City University Hospital
Aichi, Japan
Matsuyama Red Cross Hospital
Ehime, Japan
Gunma University Hospital
Gunma, Japan
Hyogo Medical University Hospital
Hyōgo, Japan
University Hospital Kyoto Prefectural University of Medicine
Kyoto, Japan
Iwate Medical University Hospital
Numakunai, Japan
National Hospital Organization Okayama Medical Center
Okayama, Japan
Osaka University Hospital
Osaka, Japan
Dokkyo Medical University Saitama Medical Center
Saitama, Japan
Japanese Red Cross Medical Center
Shibuya-ku, Japan
The Cancer Institute Hospital of JFCR
Tokyo, Japan
Yamagata University Hospital
Yamagata, Japan
SP ZOZ Szpital Uniwersytecki w Krakowie-Jakubowskiego 2;Oddzial Kliniczny Hematologii
Krakow, Lesser Poland Voivodeship, Poland
Uniwersyteckie Centrum Kliniczne
Gda?sk, Poland
Narodowy Instytut Onkologii im. Marii Sk?odowskiej-Curie - Pa?stwowy Instytut Badawczy
Warsaw, Poland
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu
Wroc?aw, Poland
Auxilio Mutuo Cancer Center
San Juan, Puerto Rico
Chonnam National University Hwasun Hospital
Jeollanam-do, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Seoul St Mary's Hospital
Seoul, South Korea
Hospital Costa del Sol
Marbella, Malaga, Spain
Clinica Universitaria de Navarra
Pamplona, Navarre, Spain
Hospital Clinic i Provincial de Barcelona
Barcelona, Spain
Hospital General Universitario Gregorio Marañon
Madrid, Spain
Hospital Clinico Universitario de Salamanca
Salamanca, Spain