Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)
Sponsor: Bassett Healthcare
Summary
The VPT Safety Trial (VPS) compares two common antibiotic combinations to see how they affect the kidneys of patients in the hospital with serious infections. Both combinations are approved by the Food and Drug Administration (FDA). The goal is to help doctors know which combination is safer so they can make better choices for their patients.
Official title: A Randomized Controlled Trial Comparing Renal Effects of Vancomycin Combined With Either Piperacillin/Tazobactam or Meropenem: VPT Patient Safety (VPS) Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
852
Start Date
2026-08-17
Completion Date
2028-12-31
Last Updated
2026-10-15
Healthy Volunteers
No
Conditions
Interventions
Piperacillin + Tazobactam
PT Dosing (concealed): PT dosing is standard irrespective of infection severity. 4.5 gm IV loading dose over 30 min, then 4.5 g IV over 4 hr (extended infusion) 6 hrs after the loading dose, and then q 8 hr
meropenem
M dosing (concealed): M dosing depends on infection severity. 1 gm loading IV dose over 30 min, then 1 gm IV over 4 hr (extended infusion) q 8 hr (default dosing). Clinician has option to increase to 2 gm IV q 8 hr for severe infections and to decrease back to default dosing if previously chosen higher dosing is no longer deemed indicated.
Locations (7)
University of Massachusetts Chan Medical School
Worcester, Massachusetts, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
Bassett Medical Center
Cooperstown, New York, United States
NY Presbyterian/Queens
Flushing, New York, United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States
Medical University of South Carolina - South Carolina Clinical & Translational Research Institute
Charleston, South Carolina, United States
West Virginia University
Morgantown, West Virginia, United States