Clinical Research Directory

Inclusion Criteria: * Previously treated neovascular (wet) age-related macular degeneration (nAMD) * Responsive to prior intravitreal anti-VEGF therapy * Study eye at screening must have an ETDRS letter score greater than 35 (20/200 Snellen equivalent) * Active choroidal neovascularization lesion in the study eye secondary to nAMD. * Central subfield thickness in the study eye of less than or equal to 370 microns. * Compliance to all study protocol requirements Exclusion Criteria: * Study eye has had previous treatment with cell therapy, brachytherapy, and/or gene therapy * History of uncontrolled intraocular pressure * Presence of any clinically significant epiretinal membrane, vitreomacular traction, subfoveal atrophy (including RPE degeneration), RPE tear in the study eye * History of vitreoretinal surgery, corneal transplant, glaucoma surgery in the study eye or cataract surgery within 3 months before screening visit * History of vitreous hemorrhage within 3 months prior to screening visit in the study eye * A clinically significant cataract (including PSC) likely to affect trial outcomes (i.e., vision) in the study eye * Anterior chamber intraocular lens, aphakia, or violation of the posterior capsule in the study eye; prior Nd:YAG laser posterior capsulotomy in association with posterior intraocular lens implantation is allowed provided it occurred at least 30 days before the screening visit * Any active bacterial, viral, fungal or parasitic ocular or periocular infection or any history of uveitis in either eye * Intraretinal fluid (IRF) in the proposed study eye of less than 30 µm confirmed by the CRC following the screening visit