Clinical Research Directory

Inclusion Criteria: 1. Diabetes mellitus combined with unresectable advanced HCC (BCLC stage C); 2. Patients who have the need for treatment, prevention and improvement of diabetic neuropathy; 3. Liver function at Child-Pugh grade A or B (≤ 7 points), ECOG PS 0-1; 4. Age 18-80 years old. Confirmed as unrectable HCC through pathological or imaging diagnosis; Exclusion Criteria: 1. Severe liver dysfunction: Child-Pugh C grade (≥ 8 points) or active hepatic encephalopathy Illness; 2. Extensive extrahepatic metastases (e.g., lung, bone, or peritoneum metastases); 3. Severe cardiovascular diseases: Uncontrolled heart failure, recent myocardial infarction; 4. Renal failure: Creatinine clearance rate \< 30 mL/min; 5. Thrombocytopenia (less than 50×10⁹/L) or coagulation dysfunction (INR greater than 1.5); 6. Active infection (such as uncontrolled hepatitis B virus replication with HBV-DNA \> 2000 IU/mL); 7. ECOG PS ≥ 2 or extremely poor overall condition; 8. Diabetic patients with acute ketoacidosis or during the period of severe infection; 9. Pregnant and lactating women; 10. Known history of other malignancy.