Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Randomized Controlled Pilot Study Evaluating Avive+ Soft Tissue Matrix for Prevention of Superficial Radial Nerve Morbidity Following Radial Forearm Free Flap Harvest
Sponsor: University of Alabama at Birmingham
Summary
Radial forearm free flap (RFFF) reconstruction is commonly used for head and neck defects but is associated with donor-site morbidity, including neuropathic pain and sensory disturbance. This randomized controlled pilot study evaluates whether placement of a soft tissue matrix over the superficial radial nerve at the donor site reduces neuropathic pain and improves sensory outcomes compared to standard closure alone.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-07
Completion Date
2029-12
Last Updated
2026-04-30
Healthy Volunteers
No
Conditions
Interventions
Standard Closure (Control)
* Standard RFFF harvest * Split-thickness skin graft (STSG) donor-site closure
Avive+ Intervention
* Standard RFFF harvest * Placement of Avive+ Soft Tissue Matrix over the superficial radial nerve * STSG donor-site closure
Locations (1)
University of Alabama at Birmingham
Birmingham, Alabama, United States