Clinical Research Directory

Inclusion Criteria:. 1. Written Informed Consent has been obtained prior to any study-related procedures taking place 2. Subject is Male or Female, 18 years of age or older prior to the initial visit 3. Is an established wearer of PROSE devices for \> 6 months in both eyes 4. Currently wears PROSE devices on a daily basis in both eyes 5. No plans to alter the PROSE lens design in either eye during the study period 6. Bilateral Demodex Blepharitis (\> Grade 2, which is more than 10 upper lash collarettes, worse eye) 7. Baseline CLDEQ-8 score of 12 or higher 8. Baseline VAS score of 40 or above for frequency OR severity in ONE of the following: tolerability, blurred vision, ocular burning, ocular redness or ocular itching 9. In the opinion of the investigator, the subject can follow study instructions 10. In the opinion of the investigator, the subject can complete all study procedures and visits \- Exclusion Criteria: 1. Is currently participating in any other type of eye-related clinical research study 2. Is pregnant or nursing as reported by the subject. 3. Has a condition or is in a situation which, in the investigator's opinion, may put the subject at significant risk, may confound study outcomes, or may significantly interfere with the subject's participation in the study. 4. Has had previous ocular surgery within the past 12 weeks or has planned ocular surgery during the study period. 5. Has initiated any new blepharitis or ocular surface treatment within the last 12 weeks 6. The subject is only wearing a PROSE device in one eye. 7. The participant is monocular 8. The participant carries a diagnosis of glaucoma or ocular hypertension or glaucoma suspect AND is currently using glaucoma medications 9. Allergy to sodium fluorescein 10. Allergy to XDEMVY (lotilaner ophthalmic solution) 0.25% \-