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Investigation of Allergen Sensitization in Newborn Babies Diagnosed With Necrotizing Enterocolitis.
Sponsor: Saglik Bilimleri Universitesi
Summary
To evaluate the frequency of allergy between 12 and 24 months of age in infants who were treated in the neonatal clinic and had NEC. To investigate the relationship between NEC development and the development of allergy in the later period.
Official title: Allergy Risk and Sensitization Following Necrotizing Enterocolitis
Key Details
Gender
All
Age Range
12 Months - 24 Months
Study Type
INTERVENTIONAL
Enrollment
130
Start Date
2026-04-01
Completion Date
2028-01-01
Last Updated
2026-05-01
Healthy Volunteers
Yes
Conditions
Interventions
skin prick test
Skin Prick Test Procedure: The SPT was performed when patients were free of acute health problems, and medications that could affect test results had been discontinued. A histamine solution (10 mg/mL, ALK-Abelló®, Canada) was used as a positive control, and 0.9% sodium chloride was used as a negative control. The test was performed on the volar surface of the forearm, and results were read after 20 minutes. A wheal ≥3 mm greater than the negative control, with erythema, was considered positive (Heinzerling L, et al. Clin Transl Allergy 2013;3:3). Sensitization to aeroallergens, including house dust mites (Dermatophagoides farinae, Dermatophagoides pteronyssinus), grass pollen mix, tree pollen mix, mold mix, cat epithelium, dog epithelium, and cockroach extract (ALK-Abelló®, Canada), was assessed. Sensitization to food allergens (cow's milk, egg, wheat, nuts, fish, and soy) was also evaluated using commercial extracts (ALK-Abelló®, Canada).