Clinical Research Directory
Browse clinical research sites, groups, and studies.
Tongyangxiao Lotion for Postoperative Wound Healing After Anal Fistula Surgery
Sponsor: Yongkang An
Summary
This study tests whether a traditional Chinese herbal bath called Tongyangxiao (TYX) lotion helps surgical wounds heal faster in patients who have had anal fistula surgery. Anal fistulas are abnormal tunnels near the anus that often require surgery, but the wound is usually left open and heals slowly. The study compares TYX lotion with a standard antiseptic bath (potassium permanganate). Patients use one of the two baths once daily for 14 days after surgery. The main goal is to see how long it takes for the wound to close completely. The study also measures pain, wound size, inflammation, and proteins involved in healing. A total of 115 patients took part, and laboratory experiments with human skin cells were also performed to understand how TYX works.
Official title: Tongyangxiao Lotion Accelerates Postoperative Wound Healing in Anal Fistula Surgery by Activating the PI3K-Akt-mTOR Pathway
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
115
Start Date
2023-06-01
Completion Date
2024-06-30
Last Updated
2026-05-01
Healthy Volunteers
No
Interventions
Tongyangxiao (TYX) group
Patients receive a 15-minute sitz bath once daily with 1500 mL of Tongyangxiao decoction (40°C) from postoperative day 2 for 14 consecutive days. The decoction contains ten herbs: Huangbai (Phellodendron chinense), Kushen (Sophora flavescens), Danggui (Angelica sinensis), Cangzhu (Atractylodes lancea), Qinjiao (Gentiana macrophylla), Xixin (Asarum sieboldii), Fangfeng (Saposhnikovia divaricata), Chuanjiao (Zanthoxylum bungeanum), Mingfan (Alumen), and Mangxiao (Natrii Sulfas).
Potassium permanganate (PP) group
atients receive a 15-minute sitz bath once daily with 1500 mL of 1:5000 potassium permanganate solution (40°C) from postoperative day 2 for 14 consecutive days.
Locations (1)
the First Affiliated Hospital of Henan University of Chinese Medicine
Zhengzhou, Henan, China