Clinical Research Directory
Browse clinical research sites, groups, and studies.
Effect of Continuous Erector Spinae Plane Block With Ropivacaine on Postoperative Pain and NF-κB Levels After Mastectomy
Sponsor: Aldy Aldy
Summary
This study aims to evaluate the effect of continuous erector spinae plane block (CESPB) using ropivacaine on postoperative pain in patients undergoing elective mastectomy. In addition to pain control, this study investigates the impact of CESPB on systemic inflammatory response as measured by nuclear factor kappa B (NF-κB) levels, opioid consumption, and quality of recovery. Patients will be randomly assigned to receive CESPB or standard analgesia without block. Outcomes will be assessed within the first 24 hours after surgery. The findings are expected to provide evidence on the clinical and biological benefits of CESPB as part of multimodal analgesia in breast surgery.
Official title: Comparison of Continuous Erector Spinae Plane Block With Ropivacaine Versus No Block on Postoperative Pain, NF-κB Levels, Opioid Consumption, and Quality of Recovery in Patients Undergoing Elective Mastectomy
Key Details
Gender
FEMALE
Age Range
30 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-05-01
Completion Date
2026-10-01
Last Updated
2026-05-01
Healthy Volunteers
No
Conditions
Interventions
Continuous Erector Spinae Plane Block
Ultrasound-guided placement of a catheter in the erector spinae plane for continuous regional analgesia.
Ropivacaine
Local anesthetic administered via continuous infusion through the erector spinae plane catheter for postoperative analgesia.
Locations (1)
Ngoerah Hospital
Denpasar, Bali, Indonesia