Clinical Research Directory

Inclusion Criteria: * Men: 18-55 years and women: 18-45 years (premenopausal). * Residence: ≥ 2 years in the participating region. * Ability to give informed consent and complete questionnaires (diet, lifestyle, occupational exposure). * Willingness to provide required samples: semen, serum, stool for men and for women serum, stool, follicular fluid and endometrial sample. * Availability for study visits and compliance with pre-analytical rules: Abstinence 2-7 days before semen collection and timed sampling in women (e.g., follicular phase or per protocol). * For patient cohort: diagnosed reproductive disorder per site SOPs (e.g., male factor infertility, endometriosis, diminished ovarian reserve). * For control cohort: no known infertility diagnosis; trying to conceive or healthy volunteers. * Necessary for all participants will be possess the ability to understand the information contained in the "informed consent" document. Exclusion Criteria: * Pregnancy or lactation. * Acute febrile illness or active urogenital/reproductive tract infection in the last 4 weeks. * Systemic therapies likely to confound biomarkers within prespecified windows: chemotherapy/radiotherapy (past 12 months), high-dose corticosteroids/immunosuppressants (past 3 months), hormonal stimulation outside scheduled ART cycles per protocol. * Substance abuse (investigator judgment) impeding consent/compliance.