Clinical Research Directory
Browse clinical research sites, groups, and studies.
JAK2 Expression in Androgenetic Alopecia Before and After Topical Minoxidil
Sponsor: Kasr El Aini Hospital
Summary
Androgenetic alopecia is a common form of progressive hair loss. This prospective single-arm pre-post interventional study aims to assess tissue Janus Kinase 2 (JAK2) expression in patients with androgenetic alopecia by comparing balding and non-balding scalp at baseline, and to evaluate changes in JAK2 expression in balding scalp after 3 months of topical minoxidil 5% therapy. Clinical response will be assessed using standardized trichoscopic parameters.
Official title: Assessment of Janus Kinase 2 Expression in Patients With Androgenic Alopecia and Its Modulation by Topical Minoxidil Therapy.
Key Details
Gender
MALE
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2026-02-01
Completion Date
2027-01-01
Last Updated
2026-05-01
Healthy Volunteers
Yes
Conditions
Interventions
Topical Minoxidil 5% Solution
Topical minoxidil 5% solution applied to the affected scalp areas for 12 weeks. Men will apply 1 cc twice daily and women will apply 1 cc once daily.
Scalp Punch Biopsy
Three 2 mm punch biopsies will be obtained during the study: one from the balding scalp area and one from the non-balding scalp area at baseline, and one from the balding scalp area after 12 weeks of treatment.
Tissue JAK2 Protein Measurement by ELISA
Tissue samples obtained from scalp punch biopsies will be analyzed for Janus Kinase 2 (JAK2) protein levels using ELISA at baseline and after 12 weeks of treatment.
Locations (1)
Kasr El Aini Hospital
Cairo, Cairo Governorate, Egypt