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Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)
Sponsor: National Institute of Cardiology, Laranjeiras, Brazil
Summary
Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or "inflammaging". The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.
Key Details
Gender
All
Age Range
60 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
62
Start Date
2026-06
Completion Date
2029-12
Last Updated
2026-05-04
Healthy Volunteers
Yes
Conditions
Interventions
Laser Speckle Contrast Imaging
Investigation of Systemic Endothelial Microvascular Function
Handgrip Dynamometry (Muscle Strength)
Serving as a marker of systemic muscle strength and sarcopenia.
Sit-to-Stand Test (5-Times Sit-to-Stand - 5STS)
This test will assess the strength and power of the lower limbs.
Single-Leg Balance Test
Failure to maintain the position (to stand on one leg) for at least 10 seconds will be correlated as a marker of frailty and risk of falls.
Assessment of Global Cognitive Function
Overall cognitive function will be assessed using the Mini-Mental State Examination.
Locations (1)
Eduardo Tibiriçá
Rio de Janeiro, Brazil