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NOT YET RECRUITING

NCT07564414

PHASE3

A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

Sponsor: Novo Nordisk A/S

View on ClinicalTrials.gov

Summary

This clinical study is testing how the study medicine CagriSema helps people living with obesity, with or without type 2 diabetes (T2D), lose weight. The purpose of the study is to find out how safe and effective CagriSema is for body weight loss in these participants. Participants will receive either CagriSema or semaglutide, and which treatment participants receive is decided by chance. CagriSema is a new study medicine being tested, while semaglutide is a medicine that doctors can already prescribe. The study will last for about 83 weeks

Official title: A Clinical Study to Compare Efficacy and Safety of Two Different Doses of CagriSema and Semaglutide in Participants With Obesity With or Without Type 2 Diabetes

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

2500

Start Date

2026-05-21

Completion Date

2028-04-19

Last Updated

2026-05-04

Healthy Volunteers

Conditions

Obesity Type 2 Diabetes

Interventions

DRUG

Cagrisema

Cagrisema (Cagrilintide and Semaglutide) will be administered subcutaneously.

DRUG

Semaglutide

Semaglutide will be administered subcutaneously.

Locations (302)

Uni of Alabama at Birmingham

Birmingham, Alabama, United States

Cahaba Research

Pelham, Alabama, United States

Elligo Health Research Inc

Gilbert, Arizona, United States

Velocity Clinical Research-Phoenix

Phoenix, Arizona, United States

Arkansas Clinical Research

Little Rock, Arkansas, United States

Woodland Int. Research Group

Little Rock, Arkansas, United States

Headlands Research California, LLC

Escondido, California, United States

Neighborhood Healthcare

Escondido, California, United States

Diabetes & Endocrine Specialists - La Mesa

La Mesa, California, United States

Clinical Trials Research_Sacramento

Lincoln, California, United States

Loma Linda University Faculty Medical Clinics

Loma Linda, California, United States

Pacific Clinical Studies

Los Alamitos, California, United States

Valley Clinical Trials

Northridge, California, United States

Desert Oasis Healthcare

Palm Springs, California, United States

Linda Vista Health Care Ctr

San Diego, California, United States

Velocity Clin Res - Van Nuys

Van Nuys, California, United States

Flourish Research - CA

Walnut Creek, California, United States

University of Colorado Hospital

Aurora, Colorado, United States

TBMR & Alcanza

Clearwater, Florida, United States

Northeast Research Institute

Fleming Island, Florida, United States

Northeast Research Institute

Jacksonville, Florida, United States

Westside Center For Clinical Research

Jacksonville, Florida, United States

Bioclinical Research Alliance

Miami, Florida, United States

New Horizon Research Center

Miami, Florida, United States

South Broward Research LLC

Miramar, Florida, United States

West Orange Endocrinology

Ocoee, Florida, United States

Oviedo Medical Research, LLC

Oviedo, Florida, United States

Clinical Trial Services Corp

Pembroke Pines, Florida, United States

Hope Clin Res & Wellness

Conyers, Georgia, United States

Center for Adv Res & Education

Gainesville, Georgia, United States

Endocrine Research Solutions, Inc

Roswell, Georgia, United States

North Georgia Clinical Research

Woodstock, Georgia, United States

Solaris Clinical Research

Meridian, Idaho, United States

Cedar-Crosse Research Center

Chicago, Illinois, United States

Macoupin Fam Practice Ctr, LLP

Gillespie, Illinois, United States

Clinical Investigation Spec Gurnee

Gurnee, Illinois, United States

Endeavor Health

Skokie, Illinois, United States

Evanston Premier Hlthcr Res

Skokie, Illinois, United States

Iowa Diabetes Research

West Des Moines, Iowa, United States

Alliance for Multispecialty Research

Newton, Kansas, United States

Cotton O'Neil Diab & Endo Ctr

Topeka, Kansas, United States

The Research Group of Lexington LLC

Lexington, Kentucky, United States

Endo and Metabolic Consultants

Rockville, Maryland, United States

Northern Pines Hlth Ctr, PC

Buckley, Michigan, United States

International Diabetes Center

Minneapolis, Minnesota, United States

AES Minneapolis DRS

Richfield, Minnesota, United States

Belzoni Clinical Research

Belzoni, Mississippi, United States

Clinical Research Professionals

Chesterfield, Missouri, United States

Amicis Centers of Clinical Research

St Louis, Missouri, United States

Southgate Medical Group, LLP

West Seneca, New York, United States

PharmQuest Life Sciences LLC

Greensboro, North Carolina, United States

Physician's East Endocrinology

Greenville, North Carolina, United States

Carteret Medical Group

Morehead City, North Carolina, United States

Centricity Rsrch MHCity Multi

Morehead City, North Carolina, United States

Piedmont Healthcare/Research

Statesville, North Carolina, United States

Accellacare Wilmington

Wilmington, North Carolina, United States

Lillestol Research LLC

Fargo, North Dakota, United States

Plains Clinical Research Center, LLC

Fargo, North Dakota, United States

Advanced Medical Research

Maumee, Ohio, United States

Alliance for Multispecialty Research

Norman, Oklahoma, United States

Lynn Institute of Norman

Norman, Oklahoma, United States

Heritage Valley Medical Group

Beaver, Pennsylvania, United States

Hatboro Med Associates

Hatboro, Pennsylvania, United States

Northeast Endocrine Metabolic Associates

Philadelphia, Pennsylvania, United States

Clinical Res Collaborative

Cumberland, Rhode Island, United States

Velocity Clinical Research-Gaffney

Gaffney, South Carolina, United States

Spartanburg Medical Research

Spartanburg, South Carolina, United States

Jackson Clinic

Jackson, Tennessee, United States

Holston Medical Group

Kingsport, Tennessee, United States

CNS Healthcare

Memphis, Tennessee, United States

HealthStar Physicians, PC

Morristown, Tennessee, United States

Clinical Research Associates

Nashville, Tennessee, United States

Amarillo Med Spec LLP

Amarillo, Texas, United States

Texas Diab & Endo, P.A.

Austin, Texas, United States

Velocity Clinical Research Austin

Austin, Texas, United States

Velocity Clin Res, Dallas

Dallas, Texas, United States

North Texas Endocrine Center

Dallas, Texas, United States

Cedar Health Research

Euless, Texas, United States

JCCT- Juno NW Houston

Houston, Texas, United States

The Endocrine Center

Houston, Texas, United States

Medical Colleagues-Texas LLP

Katy, Texas, United States

Sante Clinical Research

Kerrville, Texas, United States

Radiance Clinical Research

Lampasas, Texas, United States

Aeres Clinical Research

Laredo, Texas, United States

DCOL Ctr for Clin Res

Longview, Texas, United States

RGV Endocrine Center

McAllen, Texas, United States

Quality Research Inc

San Antonio, Texas, United States

AES San Antonio

San Antonio, Texas, United States

Northeast Clinical Research of San Antonio

San Antonio, Texas, United States

Consano Clinical Research, LLC

Shavano Park, Texas, United States

Mt Olympus Medical Research, LLC

Sugar Land, Texas, United States

J.Lewis Research Inc

Salt Lake City, Utah, United States

J.Lewis Research Inc

Salt Lake City, Utah, United States

Diabetes & Endo Tx Specialists

Sandy City, Utah, United States

J.Lewis Research Inc

South Jordan, Utah, United States

Health Res of Hampton Roads

Newport News, Virginia, United States

Tidewater Physicians Multispecialty Group

Newport News, Virginia, United States

National Clin Res Inc.

Richmond, Virginia, United States

Prevea Health

Green Bay, Wisconsin, United States

CEMEDIC

CABA, Buenos Aires, Argentina

Centro de Investigaciones Metabólicas

Capital Federal, Buenos Aires, Argentina

CICEMO- Consultorio (Av Directorio)

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Centro Médico Arsema

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Centro de Investigación C.I.C.E 9 de Julio - Sanatorio 9 de Julio

San Miguel de Tucumán, Tucumán Province, Argentina

OMI- Organización Médica de Investigación

Buenos Aires, Argentina

Kynet Recoleta

Buenos Aires, Argentina

Hospital Sirio Libanes

Buenos Aires, Argentina

Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli

Buenos Aires, Argentina

CEDIC Centro de Investigación Clínica

CABA, Argentina

CIPREC Arenales

CABA, Argentina

Centro Médico Viamonte SRL

CABA, Argentina

Instituto Centenario

Ciudad de Buenos Aires, Argentina

CEDIR - Centro de diagnóstico y rehabilitación Santa Fe

Santa Fe, Argentina

Sanatorio Norte

Santiago del Estero, Argentina

Sydney Clinical Trials

Campbelltown, New South Wales, Australia

Gosford Renal Research

Gosford, New South Wales, Australia

Sydney Cardiometabolic Centre

Liverpool, New South Wales, Australia

Hunter Diabetes Centre

Merewether, New South Wales, Australia

University of Sunshine Coast - Vitality Village

Birtinya, Queensland, Australia

University of Sunshine Coast - South Brisbane

South Brisbane, Queensland, Australia

Emeritus Research Melbourne

Camberwell, Victoria, Australia

Medical University of Graz

Graz, Austria

Ordination Winhofer-Stöckl

Mattersburg, Austria

Fließer-Görzer [Ordination]

Saint Stefan, Austria

Klinik Landstraße

Vienna, Austria

Universitätsklinikum AKH Wien

Vienna, Austria

Ordination Dr. Günter Sokol

Vienna, Austria

Klinik Hietzing 3. Med. Abt.

Vienna, Austria

Itariu [Ordination]

Vienna, Austria

Anima Research Center

Alken, Belgium

Cliniques universitaires Saint-Luc

Brussels, Belgium

KORMONT

Kluisbergen, Belgium

CHU Tivoli

La Louvière, Belgium

MECLINAS

Mechelen, Belgium

AZ Delta - Roeselare

Roeselare, Belgium

KORMONT

Zwalm, Belgium

MC For Life EOOD

Burgas, Bulgaria

MC Kazanlak EOOD

Kazanlak, Bulgaria

Medical center Medi City 21 OOD

Kyustendil, Bulgaria

OCSOMCE - Dr. Albena Dinkova EOOD

Pleven, Bulgaria

AIPSMCEMDID - Dr. Georgi Levterov EOOD

Plovdiv, Bulgaria

DCC Sveti Georgi EOOD

Plovdiv, Bulgaria

Hipocrat 9 - Dr. Rumyana Boykova - Draganova - AISPEMD EOOD

Sofia, Bulgaria

DCC XX - Sofia EOOD, Endocrinology

Sofia, Bulgaria

MC Diamedical - 2013 OOD, Sofia

Sofia, Bulgaria

Medical Centre Medical Arts Medico-dental centre

Sofia, Bulgaria

DCC XXV Sofia EOOD, Endocrinology Consulting room

Sofia, Bulgaria

UMHAT Prof. Dr. Stoyan Kirkovich AD

Stara Zagora, Bulgaria

AIPSMC Dr. Evelina Zlatanova EOOD

Varna, Bulgaria

MC Nevromedics EOOD, Internal Diseases

Veliko Tarnovo, Bulgaria

C-Health Partners

Calgary, Alberta, Canada

Medical Arts Health Research Group_Kelowna

Kelowna, British Columbia, Canada

Ocean West Research Clinic

Surrey, British Columbia, Canada

Hilltop Medical Clinic

Surrey, British Columbia, Canada

Dr. M.B. Jones Inc

Victoria, British Columbia, Canada

G.A. Research Associates Ltd.

Moncton, New Brunswick, Canada

Nova Scotia Hlth Halifax

Halifax, Nova Scotia, Canada

Care Access Cape Breton

Sydney, Nova Scotia, Canada

Centricity Research Brampton Endocrinology

Brampton, Ontario, Canada

Apex Trials

Guelph, Ontario, Canada

Hamilton Medical Research Group

Hamilton, Ontario, Canada

Wharton Medical Clinic Clinical Trials (Hamilton)

Hamilton, Ontario, Canada

Premier Clinical Trial Research Network (PCTRN)

Hamilton, Ontario, Canada

Milestone Research

London, Ontario, Canada

Bluewater Clin Res Group Inc

Sarnia, Ontario, Canada

Diabetes Heart Research Centre

Toronto, Ontario, Canada

Centre Medical Acadie

Montreal, Quebec, Canada

Centricity Res Pointe-Claire

Pointe-Claire, Quebec, Canada

Diex Recherche Quebec

Québec, Canada

Alpha Recherche Clinique - Lebourgneuf

Québec, Canada

Fakultní nemocnice U sv. Anny v Brně

Brno, Czechia

Centrum zdraví Dolní Břežany, a.s.

Dolní Břežany, Czechia

KARDIOLOGIE - LIBEREC s.r.o.

Liberec, Czechia

Interní a diabetologická ordinace s.r.o.

Náchod, Czechia

DIALINE s.r.o.

Plzeň 3, Czechia

ENDOTRIAL s.r.o.

Prague, Czechia

Milan Kvapil s.r.o.

Prague, Czechia

EUC Klinika Praha a.s.

Prague, Czechia

Fledip s.r.o.

Prague, Czechia

CHU ROUEN_HOPITAL DE BOIS GUILLAUME_Service de Nutrition

Bois-Guillaume, France

CENTRE HOSPITALIER DE COLMAR_Endocrinologie/Diabetologie/Centre Nutritionnel

Colmar, France

LES HOPITAUX DE CHARTRES_HOPITAL LOUIS PASTEUR_Service d'endocrinologie

Le Coudray, France

APHP - LA PITIE SALPETRIERE _ Service de Nutrition

Paris, France

HOPITAL EUROPEEN GEORGES POMPIDOU_Service de nutrition et diabétologie

Paris, France

CHU DE BORDEAUX-HOPITAL HAUT LEVEQUE_Service d'Endocrinologie, Diabétologie et Maladies Métaboliques

Pessac, France

HCL-HOPITAL LYON SUD_Service d'Endocrinologie-Diabète-Nutrition

Pierre-Bénite, France

CHU NANTES - HOPITAL NORD LAENNEC_Service d'Endocrinologie-Diabétologie-Nutrition

Saint-Herblain, France

CENTRE DE RECHERCHE CLINIQUE PORTES DU SUD_Service d'Endocrinologie-Diabétologie-Maladies Métaboliques

Vénissieux, France

University General Hospital Of Alexandroupoli - First Department of Internal Medicine

Alexandroupoli, Greece

Evangelismos S.A. - Endocrinology department

Athens, Greece

Laiko General Hospital Of Athens - 1st department of Internal Medicine

Athens, Greece

Athens Medical Center S.A. (Iatriko Psychicou) - Department of Internal Medicine & Metabolic Diseases

Athens, Greece

General Hospital Of Athens Alexandra - Clinical Therapeutics

Athens, Greece

General Hospital Of Lamia - Internal Medicine Clinic

Lamia, Greece

Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit

Marousi, Greece

Athens Medical Center S.A. (Iatriko P. Falirou) - Diabetes and Clinical Research Center

Palaió Fáliro, Greece

Athens Medical Center S.A. (Iatriko Peristeriou) - Diabetes, obesity and cardiometabolic diseases department

Peristeri, Greece

Athens Medical Center S.A., European Interbalkan Medical Center - Department of Internal Medicine

Thessaloniki, Greece

General Hospital Of Thessaloniki G Gennimatas - Internal Medicine Clinic

Thessaloniki, Greece

NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes

Thessaloniki, Greece

Thermi Clinic S.A. - Diabetes and Internal Medicine Department

Thessaloniki, Greece

Dr. Lakatos Ferenc Kardiológus ,Belgyógyász Magán szakrendelés

Békéscsaba, Bekes County, Hungary

Lausmed Kft.

Baja, Bács-Kiskun county, Hungary

Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ

Szeged, Csongrád-Csanád, Hungary

Óbudai Egészségügyi Centrum

Budapest, Pest County, Hungary

Szatmári-Med Kft.

Budapest, Pest County, Hungary

Medifarma-98 Kft.

Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary

EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság

Baja, Hungary

Békés Vármegyei Központi Kórház

Békéscsaba, Hungary

Trial Pharma Kft.

Békéscsaba, Hungary

Biatros Kft.

Biatorbágy, Hungary

Semmelweis Egyetem

Budapest, Hungary

Cardiogeneral Kft.

Budapest, Hungary

Mentaház Kft.

Székesfehérvár, Hungary

Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház-Rendelőintézet

Szolnok, Hungary

AOU IRCCS Policlinico di Sant'Orsola Malpighi - UOC Endocrinologia e Prevenzione e Cura del Diabete

Bologna, Emilia-Romagna, Italy

IRCCS Ospedale Policlinico San Martino - U.O.D. Dietetica e Nutrizione Clinica

Genoa, Liguria, Italy

Spedali Civili Brescia - SSD Endocrinologia

Brescia, Lombardy, Italy

Ospedale San Raffaele S.r.l. - Unità di Cardio-metabolismo e Trials Clinici

Milan, Lombardy, Italy

Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia

Perugia, Pg, Italy

D.A.I. Oncologico - U.O.C. di Chirurgia Generale ad indirizzo Oncologico

Messina, Sicily, Italy

INRCA Ancona - UOC Clinica Medica e Geriatrica

Ancorna, The Marches, Italy

Azienda Ospedaliero Universitaria Pisana

Pisa, Tuscany, Italy

Azienda Ospedaliero-Universitaria Renato Dulbecco

Catanzaro, Italy

PreCare Trial & Recruitment

Born, Limburg, Netherlands

Progress Clinical Research Den Bosch

's-Hertogenbosch, North Brabant, Netherlands

Rijnstate Ziekenhuis

Arnhem, Netherlands

Catharina Zkh Eindhoven - Interne geneeskunde

Eindhoven, Netherlands

Spaarne Gasthuis Hoofddorp - Interne

Hoofddorp, Netherlands

Bethesda Diabetes Research Center en Bethesda ziekenhuis

Hoogeveen, Netherlands

Ikazia Ziekenhuis

Rotterdam, Netherlands

Medisch Centrum Thomsonplein

The Hague, Netherlands

Uniwersytecki Szpital Kliniczny w Bialymstoku

Bialystok, Poland

Gabinet Leczenia Otylosci i Chorob Dietozaleznych

Bialystok, Poland

Kresmed Sp. z o. o.

Bialystok, Poland

Renew Clinic Sp. z o.o.

Bialystok, Poland

Gierach-Med

Bygdoszcz, Poland

ETG Lublin Sp. z o.o.

Dębica, Poland

Pro Familia Altera Sp. z o.o.

Katowice, Poland

Vita Longa Sp. z o. o.

Katowice, Poland

Małopolskie Centrum Kliniczne

Krakow, Poland

Maciej Wiza Gaja Poradnie Lekarskie

Poznan, Poland

Centrum Medyczne Medyk Sp.zo.o. Sp.k.

Rzeszów, Poland

Gyncentrum Sp. z o. o.

Warsaw, Poland

Medon Clinical Research Sp. z o.o.

Warsaw, Poland

Wojewódzki Szpital Specjalistyczny im. J. Gromkowskiego

Wroclaw, Poland

Centrum Medyczne Oporow

Wroclaw, Poland

ULS Almada-Seixal E.P.E. - HGO_Serviço de Endocrinologia

Almada, Portugal

ULS Do Oeste E.P.E. - Unidade Caldas da Rainha_CAMI - Unidade de Diabetes

Caldas da Rainha, Portugal

ULS Do Baixo Mondego, E.P.E. - HDFF_Serviço Cardiologia

Figueira da Foz Municipality, Portugal

Hospital da Luz Lisboa, S.A._Serviço de Medicina Interna

Lisbon, Portugal

ULS De Matosinhos, E.P.E - HPH_Serviço de Endocrinologia

Senhora Da Hora, Matosinhos, Portugal

Ucardio Centro Clinico Unidade Cardiovascular

Torres Novas, Portugal

Hospital Trofa Saude Senhor do Bonfim S.A_Unidade de Ensaios Clínicos

Vila do Conde, Portugal

Hospital da Luz Arrábida, S.A_Serviço de Endocrinologia

Vila Nova de Gaia, Portugal

Grandmed SRL

Oradea, Bihor County, Romania

S.C. Top Diabet Srl

Craiova, Dolj, Romania

CMI Dr Pop Lavinia

Baia Mare, Maramureş, Romania

Sc Mediab Srl

Târgu Mureş, Mureș County, Romania

Mariodiab Clinic SRL

Brasov, Romania

Sc Nicodiab Srl

Bucharest, Romania

Mat Cord Biomedica S.R.L.

Buzău, Romania

Spitalul Clinic Judetean De Urgenta Bihor

Oradea, Romania

Sc Sal Med Srl

Piteşti, Romania

Cabinet Medical Dr Geru SRL

Timișoara, Romania

Spitalul Clinic Judetean De Urgenta Pius Brinzeu Timisoara

Timișoara, Romania

DIA - CLARUS s.r.o.

Bojnice, Slovakia

KARDIO-SANUS, spol. s r.o.

Bratislava, Slovakia

MEDISPEKTRUM s.r.o.

Bratislava, Slovakia

Diab - Int, s.r.o.

Bytča, Slovakia

HUMAN-CARE, s.r.o.

Košice, Slovakia

ENDOMED, s.r.o.

Košice, Slovakia

DIAMARTIN, s. r. o.

Martin, Slovakia

LUDIA, s. r. o.

Spišská Nová Ves, Slovakia

Phoenix Pharma

Port Elizabeth, Eastern Cape, South Africa

IATROS International

Bloemfontein, Free State, South Africa

Medi-Clinic Bloemfontein

Bloemfontein, Free State, South Africa

Soweto Clinical Trial Centre