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NOT YET RECRUITING
NCT07564674
NA

Investigating the Bioavailability of Broccoli Extract Supplements

Sponsor: Oregon State University

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to compare how much glucoraphanin and sulforaphane from 3 different versions of broccoli extract supplements is absorbed into the body and excreted in urine. This study involves generally healthy adults age 18-60 years. The supplements contain glucoraphanin and myrosinase enzyme, both naturally occurring in cruciferous vegetables. Once ingested, glucoraphanin is converted to the bioactive compound sulforaphane, which is thought to have numerous health benefits, including cancer prevention. Participants will: * consume 3 different versions of broccoli extract supplements (glucoraphanin will range from 35-70 mg) * complete 3 separate 24 hour study cycles * submit blood and urine samples for 24 hours * follow diet restrictions (no cruciferous vegetables or condiments or phytochemical/herbal supplements for 1 week prior to and during each study cycle)

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

12

Start Date

2026-09

Completion Date

2028-09

Last Updated

2026-05-04

Healthy Volunteers

Yes

Conditions

Interventions

DIETARY_SUPPLEMENT

Avmacol Extra Strength with coating - 1 tablet

Participants will swallow by mouth 1 tablet Avamacol Extra Strength with coating (35 mg glucoraphanin per tablet)

DIETARY_SUPPLEMENT

Avmacol chewable wafer - 2 tablets

Participants will chew and swallow by mouth 2 wafers Avmacol chewable wafers (30 mg glucoraphanin per wafer)

DIETARY_SUPPLEMENT

Avmacol Extra Strength with coating - 2 tablets

Participants will swallow by mouth 2 tablets Avamacol Extra Strength with coating (35 mg glucoraphanin per tablet)