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Cohort Study of PPP Injections for Athletes With Muscle Injury
Sponsor: University of Colorado, Denver
Summary
The investigators hypothesize that a single injection of platelet-poor plasma (PPP) into an acute muscle injury will significantly improve local muscle regeneration and patient outcomes compared to the standard of care using only ultrasound-guided hematoma aspiration. Muscle regeneration will be assessed through quantitative MRI analysis. The investigators anticipate that PPP injections will lead to a measurable reduction in scar tissue and an increase in regenerated muscle tissue at the injury site over a six-month period.
Official title: Prospective Cohort Study of Athletes Following an Injection of Platelet-Poor Plasma Into an Acute Muscle Injury
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2026-05-01
Completion Date
2030-12-31
Last Updated
2026-05-06
Healthy Volunteers
No
Conditions
Interventions
Platelet Poor Plasma (PPP) Injection
US-guided aspiration of hematoma (if present) and injection of small volume (1-6cc's) of autologous platelet poor plasma (PPP) at the site of injury and post-injection physical therapy.
Locations (3)
University of Colorado | Steadman Hawkins Clinic Denver
Englewood, Colorado, United States
Emory University
Atlanta, Georgia, United States
University of Iowa
Iowa City, Iowa, United States