Clinical Research Directory

Inclusion Criteria: * Adults aged 40 years and older diagnosed with knee OA based on the American College of Rheumatology (ACR) criteria. * Patients who are willing to participate and provide informed written consent.Exclusion Criteria: * Inflammatory arthritis: patients with rheumatoid arthritis, gouty arthritis, or systemic lupus erythematosus (SLE) to avoid confusion with inflammatory muscle wasting. * Physical Limitations: amputees or those with severe physical deformities preventing gait speed tests or handgrip measurement. * Patients with cardiac pacemakers or implanted electronic devices (as these interfere with Bioelectrical Impedance Analysis (BIA)). * Severe Comorbidities: end-stage renal or hepatic disease, advanced malignancy or cachexia. * Severe neurological disorders (e.g., Parkinson's disease, Stroke with paralysis) that directly affect muscle mass and mobility. * Prolonged use of systemic corticosteroids (which cause secondary sarcopenia)