Clinical Research Directory

Inclusion Criteria: * Diagnosis of CF established by either genetic screening or positive chloride sweat test (Sweat chloride concentrations \> 60mmol/L). * Diagnosis of NCFB or COPD requiring regular use of airway clearance therapy. * Age older than 11 years. * History of chronic daily sputum production. * Currently on a home therapeutic regimen that includes some form of ACT performed at least once daily that also includes concomitant use of an inhaled mucolytic and inhaled bronchodilator. * Stage I eligibility for the 3 subjects will require patients who have had ≥2 ACT session with the VEST® in-clinic with lung function measured pre-post therapy. * FVC and FEV1 \> 35%-predicted, and with stable lung function (no greater than a 10% variation in lung function parameters over the preceding 2 months). * Evaluated at the Ventura County Medical Center 2 or more times in the preceding 12 months. * Signed informed consent given by the subject, or the parents, or a legally acceptable representative. If required by the Institutional Review Board/Ethics Committee (IRB/IEC), assent will be given by the subject. * Ability to understand study requirements and comply with study procedures. Individuals of all ethnicities are included. Exclusion Criteria: * Hospitalization for CF pulmonary complications in the 2 months preceding enrollment. * Hemoptysis \> 60 cc in a single episode in the 4 weeks preceding enrollment. * Chronic chest pain. * Participation in another clinical trial in the previous 30 days. * Use of intravenous antibiotics in the 2 months preceding enrollment. * Inability or unwillingness of the participant to give written informed consent.