Clinical Research Directory

Inclusion Criteria: 1. Age 20-45 years; 2. Infertile women meeting the diagnostic criteria for diminished ovarian reserve (DOR); The following two criteria must be met simultaneously: ① Anti-Müllerian hormone (AMH) ≤0.5 ng/ml, ② Bilateral ovarian antral follicles (AFC) ≤5 (3-9 mm). 3. Patients scheduled for IVF (in vitro fertilization)/ICSI (intracytoplasmic sperm injection) treatment; 4. Patients who plan for whole embryo cryopreservation and intend to undergo another ovulation induction cycle within 4 natural months starting from the first cycle, with the goal of embryo retrieval and embryo banking; 5. Bilateral follicles were observed during AFC examination; 6. The planned ovarian stimulation protocol is one of PPOS, antagonist, or microstimulation protocols; 7. The first ovulation induction protocol is planned to be consistent with the second ovulation induction protocol; 8. Voluntary participation in the study and signing of the informed consent form. Exclusion Criteria: 1. Patients with the following reproductive and gynecological comorbidities: history of salpingectomy, ovarian cysts (e.g., chocolate cysts), ovarian tumors, or simple cysts ≥10 mm (not eligible for enrollment in the current cycle; may be enrolled after regression), history of ovarian surgery, endometriosis or adenomyosis, or acute pelvic inflammatory disease; 2. Patients with abnormal ovarian position who are expected to experience difficulties during oocyte retrieval puncture; 3. Patients with concomitant systemic severe diseases (history of severe chronic diseases such as heart failure, myocardial infarction, stroke, end-stage renal disease; advanced cancer or other terminal illnesses with an estimated survival period of less than 6 months; coagulation disorders; uncontrolled sepsis; autoimmune diseases; poor general condition rendering anesthesia and surgery intolerable); 4. Patients with contraindications to hormone replacement therapy; 5. Currently undergoing treatment with cytotoxic drugs, glucocorticoids or other immunosuppressants, radiotherapy or chemotherapy, or having previously received radiotherapy or chemotherapy; 6. One spouse has chromosomal abnormalities; 7. Patients with a history of uncontrolled epilepsy, central nervous system disorders, or psychiatric disorders, where the investigator determines that clinical severity affects compliance with the clinical study; 8. Patients who have undergone oocyte retrieval or ovarian puncture within the past year; 9. Participating in other clinical trials.