Clinical Research Directory

Inclusion Criteria: * 18-65 years of age * Diagnosis of Lennox-Gastaut Syndrome (LGS) with confirmed generalized seizures, including generalized tonic or tonic-clonic (GTC) seizures. Participants may also have complex partial, atypical absences or atonic seizures, but these will not count toward minimum seizure frequency eligibility. * Diagnosis is based on prior video EEG confirmation performed in the last 3 years. Scalp EEG showing slow spike-wave discharges and paroxysmal fast activity. * At least four seizures per month (GTC or tonic) on average during the three months preceding enrollment. * Medically intractable epilepsy, defined as failure to achieve acceptable seizure control despite trials of at least two antiseizure medications (ASMs). * Nonlocalized seizures, as determined by standard diagnostic studies. * Stable doses of two or more ASMs for at least one month prior to enrollment (rescue benzodiazepines for acute seizure clusters permitted). * Participants with vagus nerve stimulation (VNS) must have stable settings for at least two months prior to enrollment and throughout the study. * Subjective reporting of sleep disturbances. * Participant or legal guardian can provide informed consent and maintain an online seizure log, alone or with assistance. * Participant is willing to remain on a stable ASM regimen (except use of variable dose of rescue medications permitted) throughout the study and able to attend scheduled clinic visits. * Reliable caregiver is available to assist with seizure diary maintenance. Exclusion Criteria: * Predominant seizure type is focal-onset seizures. * Anatomical brain abnormalities precluding DBS implantation, or discrete brain lesions on MRI (e.g., cortical malformation, tuber, or sclerosis). * Unable to obtain brain MRI due to metal that is not compatible with 3T MRI. * History of psychogenic non-epileptic seizures or unstable psychiatric disorders, including suicidal ideation or intent within the last six months. * Clinically significant medical conditions increasing risk for pre- or postoperative complications (e.g., significant cardiac or pulmonary disease, uncontrolled hypertension). * Participant is pregnant or plans to become pregnant during the study. * Participation in another therapeutic investigational drug or device study. * Requirement for diathermy treatments during physical or occupational therapy. * In the opinion of the investigator or eligibility adjudication committee, the subject is unsuitable for the procedure.