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COMPLETED
NCT07568886
NA

Albumin and Furosemide for Preventing Ovarian Hyperstimulation Syndrome in ICSI Patients

Sponsor: Al-Nahrain University

View on ClinicalTrials.gov

Summary

This study aims to evaluate whether the combination of Albumin and Furosemide can reduce the risk of Ovarian Hyperstimulation Syndrome in women undergoing intracytoplasmic sperm injection (ICSI) who are at high risk of developing this condition. Ovarian hyperstimulation syndrome is a potential complication of ovarian stimulation during assisted reproductive techniques, which can lead to symptoms such as abdominal swelling, fluid accumulation, and, in severe cases, hospitalization. Preventing this condition is important to improve patient safety and treatment outcomes. In this randomized controlled study, eligible women undergoing ICSI were assigned to receive either the combination of albumin and furosemide or standard care. The study compared the occurrence and severity of OHSS between the two groups. The results of this study may help identify an effective strategy to prevent OHSS and improve the safety of assisted reproductive treatments.

Official title: Effect of Albumin and Furosemide Combination for Prevention of Severe Ovarian Hyperstimulation Syndrome in Hyper-Responders Undergoing Intracytoplasmic Sperm Injection Cycles: A Randomized Controlled Trial

Key Details

Gender

FEMALE

Age Range

20 Years - 35 Years

Study Type

INTERVENTIONAL

Enrollment

200

Start Date

2019-04-29

Completion Date

2024-04-01

Last Updated

2026-05-06

Healthy Volunteers

No

Interventions

DRUG

Albumin (Human) 20%

Intravenous human albumin 20% (100 mL) administered immediately after oocyte retrieval.

DRUG

Furosemide

Intravenous furosemide 20 mg administered after oocyte retrieval.

DRUG

Standard luteal phase support

Routine luteal phase support according to institutional protocol.

Locations (1)

High Institute for Infertility Diagnosis and ART

Baghdad, Baghdad Governorate, Iraq