Clinical Research Directory
Browse clinical research sites, groups, and studies.
Use of Oxiris Filter in Septic Shock Patients Requiring Renal Replacement Therapy: A Retrospective Cohort Study
Sponsor: Clinica Universidad de Navarra, Universidad de Navarra
Summary
Sepsis and septic shock are major causes of mortality in critically ill patients and are frequently associated with acute kidney injury requiring renal replacement therapy. The Oxiris filter is a hemofilter designed to provide both renal support and adsorption of endotoxins and inflammatory mediators. This study aims to evaluate the association between the use of the Oxiris filter and clinical outcomes in critically ill patients with septic shock requiring renal replacement therapy. A retrospective cohort design will be used, including patients admitted to an intensive care unit who received renal replacement therapy. Outcomes such as mortality and renal function will be analyzed and compared between patients treated with Oxiris and those treated with other filters.
Official title: Impact of Oxiris Filter Use on Mortality and Renal Outcomes in Critically Ill Patients With Septic Shock Requiring Renal Replacement Therapy: A Retrospective Cohort Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
400
Start Date
2012-01-01
Completion Date
2024-12-31
Last Updated
2026-05-06
Healthy Volunteers
No
Conditions
Interventions
Oxiris filter
Hemofilter used for renal replacement therapy with cytokine and endotoxin adsorption properties.
Standard Hemofilter
Standard hemofilters used for continuous renal replacement therapy without specific adsorption properties for endotoxins or cytokines. These filters provide conventional renal support and are used according to routine clinical practice.
Locations (1)
Clínica Universidad de Navarra
Pamplona, Navarre, Spain