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Improving Patient Assessment After Acute Kidney Injury (AKI)
Sponsor: University of Nottingham
Summary
The goal of this clinical trial is to improve patient care after acute kidney injury (AKI). It has three related parts. The main questions it aims to answer are: 1. Is creatinine or cystatin a more reliable assessment of kidney function after AKI? 2. What are the experiences of patients after AKI? 3. What interventions should be recommended to improve assessment and support of patients after AKI? Participants will be asked to do one or more of: * blood tests to measure kidney function in different ways * have measurement of their body composition * complete questionnaires about their symptoms * have an interview with a researcher about their experiences * discussion to develop an action plan based on findings
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2026-02-16
Completion Date
2029-10
Last Updated
2026-05-06
Healthy Volunteers
No
Conditions
Interventions
Iohexol renal clearance measurement
Gold standard measurement of glomerular filtration rate.
Cystatin C
Estimated GFR using serum cystatin C
Creatinine
eGFR from serum creatinine level
Semi structured interview
Semi structured interview to explore patient experiences. Purposive sampling will be used to explore a wide range of perspectives and transcripts will be analysed using thematic analysis to develop codes and themes.
Participatory workshop
Group workshop using qualitative methods. Purposive sampling will be used to explore a wide range of perspectives and transcripts will be analysed using thematic analysis to develop codes and themes. These will be used to develop consensus recommendations.
Metagenome analysis
Analysis of the metagenome using faecal samples of participants after acute kidney injury
Bioimpedance analysis
Estimation of body composition
Patient reported outcome measures
EQ-5D-5L, KSQ, WHO-DAS 2.0, K10
Measurement of physical performance
Hand grip, Short physical performance battery
Locations (1)
University Hospitals of Derby and Burton NHS Foundation Trust
Derby, Derbyshire, United Kingdom