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Salivary Microbiota and Antimicrobial Resistance in Relation to Chlorhexidine Use
Sponsor: Masaryk University
Summary
This study evaluated the ecological effects of 0.06% chlorhexidine toothpaste on the salivary microbiota of healthy individuals, focusing on taxonomic composition, functional shifts, and prevalence of predicted antimicrobial resistance genes. Saliva samples were collected from eleven healthy participants at three specific time points: baseline (following a 4-week run-in period using a control toothpaste), intervention (after 12 weeks of using 0.06% chlorhexidine digluconate toothpaste), and washout (after a subsequent 12-week period using the control toothpaste). Sequencing targeted the 16S rRNA V3-V4 region.
Official title: Study Protocol for 16S rRNA Sequencing of Healthy Oral Microbiota
Key Details
Gender
All
Age Range
25 Years - 44 Years
Study Type
INTERVENTIONAL
Enrollment
11
Start Date
2022-04-11
Completion Date
2022-11-29
Last Updated
2026-05-06
Healthy Volunteers
Yes
Conditions
Interventions
0.06% Chlorhexidine Digluconate Toothpaste
Participants used the toothpaste twice daily for 12 weeks.
Locations (2)
Department of Public Health, Faculty of Medicine, Masaryk University
Brno, Czechia
Skydent s.r.o.
Brno, Czechia