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Colchicine for Autoimmune and Subacute Thyroiditis
Sponsor: Mansoura University
Summary
Thyroiditis includes inflammatory thyroid disorders such as Hashimoto's thyroiditis and subacute thyroiditis. These conditions may cause thyroid pain, neck tenderness, elevated inflammatory markers, thyroid dysfunction, fatigue, and recurrence. Current management includes observation, symptomatic treatment, nonsteroidal anti-inflammatory drugs, and corticosteroids. Although corticosteroids may be effective, relapse after tapering and treatment-related adverse effects remain limitations. Colchicine is hypothesized to reduce inflammatory activity and may improve biochemical and clinical recovery. This study will evaluate the efficacy and safety of low-dose colchicine compared with corticosteroid therapy and supportive care in adults with autoimmune or subacute thyroiditis.
Official title: Colchicine as a Novel Anti-Inflammatory Strategy in Autoimmune and Subacute Thyroiditis: A Prospective Three-Arm Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2026-07
Completion Date
2027-09
Last Updated
2026-05-06
Healthy Volunteers
No
Interventions
colchicine
Colchicine administered orally according to the study dosing protocol. Dose adjustments permitted based on tolerability and safety assessment.
Prednisolone
Prednisolone administered orally according to the study treatment protocol with dose tapering based on clinical response and safety monitoring.
NSAID
Non-steroidal anti-inflammatory drugs administered according to standard clinical practice and patient tolerance.