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Tissue Doppler Echocardiographic Assessment of Cardiac Function in Neonatal Sepsis
Sponsor: Assiut University
Summary
1. To assess myocardial function in neonates with sepsis using tissue doppler echocardiography. 2. To assess sepsis induced cardiac dysfunction. 3. To measure serum levels of sepsis markers (CBC,CRP,Blood culture) and cardiac troponin in neonatal sepsis. 4. To analyze the correlation between echocardiographic parameters and serum biomarkers. 5. To determine whether these echocardiographic techniques can serve as early predictors of cardiac involvement in neonatal sepsis.
Official title: Tissue Doppler Echocardiographic Assessment of Cardiac Function in Neonatal Sepsis and Correlation With Cardiac Troponin and Sepsis Biomarkers
Key Details
Gender
All
Age Range
1 Day - 1 Month
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2026-05-01
Completion Date
2029-05-01
Last Updated
2026-05-07
Healthy Volunteers
Yes
Conditions
Interventions
cardiac troponin, and blood culture
D) Echocardiographic examination: will be done according to the recommendation of the American Society of Echocardiography Integrated M-mode, two-dimensional (2-D) mode and pulsed and continuous wave Doppler will be used to estimate left ventricle (LV) internal dimensions including LV end diastolic dimension, LV ventricle end systolic dimension, ventricular septal thickness, posterior wall thickness, fractional shortening, mitral and tricuspid inflow velocities, and systolic pulmonary artery pressure. From the apical four-chamber planes, using pulsed wave tissue Doppler, the myocardial velocity curves of septal mitral valve annulus, lateral mitral valve annulus, and lateral tricuspid valve annulus will be recorded. The systolic wave (S) reflects the systolic function of either right or left ventricle. The early/atrial (E'/A') ratio of tricuspid and mitral valve annulus reflects the diastolic function of the right and left ventricle, respectively.
Locations (1)
Faculty of Medicine
Asyut, Egypt