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A Pragmatic Clinical Trial to Prevent Relapse for Myeloid Malignancies With Measurable Disease Prior to Allogeneic Transplant
Sponsor: Medical College of Wisconsin
Summary
This is a prospective, open-label investigation to determine whether measurable residual disease (MRD) guided assignment of maintenance therapy is effective in patients with myeloid malignancies undergoing allogeneic hematopoietic cell transplantation (HCT). Pre-HCT, patients will undergo usual disease assessments which should include immunophenotypic and/or molecular testing. Based on the results of these tests, patients may or may not be recommended to receive maintenance therapy post-transplant, depending on the presence or absence of a residual malignant clone.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
450
Start Date
2026-08-01
Completion Date
2034-02-01
Last Updated
2026-06-23
Healthy Volunteers
No
Conditions
Interventions
Maintenance Therapy
Maintenance therapy will be suggested by the PIs, however final choice of maintenance is at the discretion of the treating physician.
No intervention
Patients will receive no maintenance therapy.
Locations (1)
Froedtert & the Medical College of Wisconsin
Milwaukee, Wisconsin, United States