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The Effect of tDCS Combined With TMS on Cognitive Impairment and Motor Function After Stroke
Sponsor: Ke Dong, MD
Summary
This clinical trial aims to investigate whether transcranial electrical stimulation (tDCS) combined with transcranial magnetic stimulation(TMS) has an impact on the cognitive and motor functions of stroke patients, and to evaluate the safety of this protocol. The main objective is to answer the following question: Can electromagnetic combined stimulation of the left Dorsolateral prefrontal lobe(DLPFC) improve the performance of working memory, motor function and cognitively motor dual tasks in stroke patients? What is its mechanism of action? Participants will undergo a combined real or sham electromagnetic stimulation of 20 minutes of tDCS and 40 seconds of TMS once a day for 7 days. Researchers will compare the effects of real stimulation with sham stimulation to see if the real stimulation can bring better results to patients. Clinical evaluations (cognitive and motor scales) and functional Near-Infrared Spectroscopy(fNIRS) were conducted before and after stimulation to record relevant brain activities
Official title: The Effect of Transcranial Electrical Stimulation Combined With Transcranial Magnetic Stimulation on Cognitive Impairment and Motor Function After Stroke
Key Details
Gender
All
Age Range
30 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2026-05-01
Completion Date
2027-05-01
Last Updated
2026-05-11
Healthy Volunteers
No
Conditions
Interventions
occupational therapy
occupational therapy 1 hour a day for 7 days
real tDCS
real 20 minutes of tDCS once a day for 7 days
sham tDCS
sham 20 minutes of tDCS once a day for 7 days
real TMS
40 seconds of real TMS once a day for 7 days
sham TMS
40 seconds of sham TMS once a day for 7 days
Locations (1)
Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China