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Allopurinol in Depression
Sponsor: Tanta University
Summary
Major depressive disorder (MDD) is one of the most common psychiatric disorders with serious socioeconomic consequences on daily life and health care costs. Despite the advent of newer antidepressants that target monoamine pathways, nearly 50% of patients have no response to first-line antidepressant therapy. Thus, a combination of medications with different strategies at the beginning of treatment could provide further therapeutic benefits to MDD patients.
Official title: Allopurinol Adjuvant Therapy in Patients With Major Depressive Disorder
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2026-05-20
Completion Date
2027-05-20
Last Updated
2026-05-07
Healthy Volunteers
No
Conditions
Interventions
Sertraline 50 MG
Sertraline is an antidepressant medication of the selective serotonin reuptake inhibitor class used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder.
Allopurinol 300 MG
Allopurinol is a potent inhibitor of the enzyme xanthine oxidase and is primarily used to treat hyperuricemia and gout
Locations (1)
Tanta Unuversity
Tanta, Egypt