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VEDA Study (DHEA vs Estradiol)
Sponsor: University of Arizona
Summary
This study is being done to compare two vaginal treatments, vaginal estrogen and vaginal DHEA, that are used to treat vaginal and urinary symptoms related to menopause. These symptoms may include vaginal dryness, discomfort, painful intercourse, or urinary problems and can affect quality of life and sexual health. Women who choose to participate will be randomly assigned to use one of the two treatments for a set period of time. Participants will complete questionnaires about their symptoms and sexual health and have simple vaginal testing at the beginning and end of the study. The goal of this research is to better understand how these treatments affect vaginal health and sexual function so healthcare providers can make informed treatment decisions and improve care for postmenopausal women.
Official title: The Use of Vaginal Estrogen vs DHEA in Perimenopausal and Menopausal Women
Key Details
Gender
FEMALE
Age Range
40 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
324
Start Date
2026-06-01
Completion Date
2031-12-31
Last Updated
2026-06-17
Healthy Volunteers
Yes
Interventions
DHEA ovals
DHEA (dehydroepiandrosterone) is an inactive hormone precursor naturally produced by the body. When placed locally in the vagina, it is converted by vaginal cells into small amounts of estrogen and androgens exactly where the tissues need them. This helps restore the vaginal lining, improve moisture, and reduce pain.
Estradiol 0.01% Vag Cream
Estradiol 0.01% vaginal cream is a local (vaginal) estrogen therapy used to treat symptoms of genitourinary syndrome of menopause (GSM)-the thinning, dryness, and inflammation of vaginal and urinary tissues caused by postmenopausal estrogen decline.