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Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly
Sponsor: National Medical Research Center for Therapy and Preventive Medicine
Summary
This is a single-center randomized controlled trial evaluating the efficacy and safety of short (3 days) versus long (10 days) courses of intermittent hypoxic-hyperoxic training (IHHT) in patients with type 2 diabetes mellitus aged 50-74 years. Participants will be randomized into three groups: 3-day IHHT course (n≥100), 10-day IHHT course (n≥100), or control group receiving gas mixture with constant O2 21% for 10 days (n≥50). The primary outcomes are fasting glucose levels and HbA1c. Secondary outcomes include cardiovascular parameters, quality of life, cognitive function, and biological age.
Official title: A Single-Center Randomized Clinical Trial With Prospective Follow-up of the Efficacy and Safety of Short and Long Duration Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Mellitus Including Elderly Patients
Key Details
Gender
All
Age Range
50 Years - 74 Years
Study Type
INTERVENTIONAL
Enrollment
250
Start Date
2025-10-15
Completion Date
2027-12-15
Last Updated
2026-05-07
Healthy Volunteers
No
Conditions
Interventions
Intermittent Hypoxic-Hyperoxic Training (3 days)
Three daily sessions using HYPO-OXY-1 (OXYTERRA) device
Intermittent Hypoxic-Hyperoxic Training (10 days)
Ten daily sessions using HYPO-OXY-1 (OXYTERRA) device
Normoxic gas breathing
Ten daily sessions of breathing gas mixture with constant O2 21%
Locations (1)
National Medical Research Center for Therapy and Preventive Medicine
Moscow, Russia