Clinical Research Directory

Inclusion Criteria: * Disease Diagnosis: Clinically diagnosed with chronic periodontitis (typically Stage III or IV according to the latest periodontal disease classification). * Target Tooth Requirements: At least two non-adjacent periodontal pockets with a Probing Pocket Depth (PPD) ≥5 mm. * Clinical Attachment Level (CAL) loss ≥3 mm. * Evidence of significant alveolar bone resorption on X-ray or CBCT (bone loss exceeding one-third of the root length). * Age and General Condition: Typically aged 18-70 years, in good general health, and able to complete the 12-month follow-up. * Oral Hygiene Awareness: Subjects are willing to receive conventional periodontal basic treatment (SRP) and demonstrate a good willingness to maintain oral hygiene (e.g., plaque index controlled at a low level). Exclusion Criteria: * Systemic Diseases: Presence of severe, uncontrolled systemic diseases (e.g., diabetes with HbA1c \>7%, active hepatitis, tuberculosis). History of malignancy or immunodeficiency diseases (due to the proliferative potential of stem cells, cancer risk must be strictly excluded). * Local Interfering Factors: Target teeth with severe mobility (Grade III mobility) or non-restorable residual crowns/roots. Received periodontal surgical treatment or systemic antibiotics within the past 3 months. * Special Populations and Habits: Heavy smokers (typically defined as smoking \>10 cigarettes per day), as smoking significantly inhibits the regenerative effect of stem cells and local blood supply. Pregnant or breastfeeding women. Individuals allergic to any components of the study preparation (e.g., specific biological carriers).