Clinical Research Directory

Inclusion Criteria: * Women, transgender men, and nonbinary individuals aged 30 to 75 who have a cervix. * No history of hysterectomy or cervical cancer. * No documented cervical cancer screening within guideline-recommended intervals: specifically, no Pap test in the past 3.5 years, no Pap/HPV co-test in the past 5.5 years, and no standalone HPV test results in the past 5.5 years. (A 6-month grace period is included to allow time for response to usual care outreach.) * At least two visits to University Hospital ambulatory care over the past five years, ensuring opportunity for follow-up and continuity of care. Exclusion Criteria: * History of cervical dysplasia within the past 3.5 years, reflecting those likely under active surveillance or treatment protocols. * Currently pregnant, due to differing screening recommendations and clinical considerations. * Prior or current diagnosis of cervical cancer or ongoing treatment for cervical neoplasia. * Physical, cognitive, or functional limitations that would preclude use of the mailed self-sampling kit without assistance. Examples include severe arthritis or significant impairment affecting self-collection capability. * Lack of a telephone number or reliable mailing address on file. * Inability to communicate in English or Spanish, given study materials and staffing capabilities. Use of additional language services is not available. * Current enrollment in other cervical cancer screening or intervention studies that may interfere with participation or outcomes. * Inability to provide informed consent or comprehend study procedures based on cognitive capacity, as assessed by the Research Coordinator during initial contact.