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NOT YET RECRUITING
NCT07575893
PHASE1

CD30 CAR-T Cells for Low Risk Relapsed Classical Hodgkin Lymphoma

Sponsor: New York Medical College

View on ClinicalTrials.gov

Summary

Patients with relapsed low-risk CD30 classical Hodgkin Lymphoma will have autologous CD30 CAR T-cell manufactured. Dose escalation will be used to determine the RP2D. Following lymphodepletion, CAR T-cell will be infused.

Official title: REACH-CD30: Reinduction Therapy Followed by Engineered Autologous CD30.CAR T Cells in Children, Adolescents and Young Adults With Lower-Risk CD30+ Relapsed Classical Hodgkin Lymphoma NYMC 628

Key Details

Gender

All

Age Range

6 Years - 29 Years

Study Type

INTERVENTIONAL

Enrollment

12

Start Date

2026-10-01

Completion Date

2032-12-01

Last Updated

2026-05-20

Healthy Volunteers

No

Interventions

BIOLOGICAL

CD30+ CAR T-cells

patients with cHL with a good response following reinduction therapy will receive autologous CD30 CAR T-cells 1-14 days following lymphodepletion

DRUG

Bendamustin

Patients will receive 70 mg/m2/day × 3 days prior to CD30 CAR T-cells

DRUG

Fludarabine

Patients will received 30 mg/m2/day × 3 days prior to CD30 CAR T-cells.