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CD30 CAR-T Cells for Low Risk Relapsed Classical Hodgkin Lymphoma
Sponsor: New York Medical College
Summary
Patients with relapsed low-risk CD30 classical Hodgkin Lymphoma will have autologous CD30 CAR T-cell manufactured. Dose escalation will be used to determine the RP2D. Following lymphodepletion, CAR T-cell will be infused.
Official title: REACH-CD30: Reinduction Therapy Followed by Engineered Autologous CD30.CAR T Cells in Children, Adolescents and Young Adults With Lower-Risk CD30+ Relapsed Classical Hodgkin Lymphoma NYMC 628
Key Details
Gender
All
Age Range
6 Years - 29 Years
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2026-10-01
Completion Date
2032-12-01
Last Updated
2026-05-20
Healthy Volunteers
No
Conditions
Interventions
CD30+ CAR T-cells
patients with cHL with a good response following reinduction therapy will receive autologous CD30 CAR T-cells 1-14 days following lymphodepletion
Bendamustin
Patients will receive 70 mg/m2/day × 3 days prior to CD30 CAR T-cells
Fludarabine
Patients will received 30 mg/m2/day × 3 days prior to CD30 CAR T-cells.