Clinical Research Directory

Inclusion Criteria: * 1.Patients with malignant hematologic diseases eligible for allogeneic hematopoietic stem cell transplantation, including MDS-RAEB, acute leukemia, and chronic phase of CML. 2.Availability of an HLA-matched sibling donor, unrelated donor, or haploidentical donor. 3.Age ≥ 14 years. 4.Liver function: ALT and AST ≤ 2.5 × upper limit of normal (ULN), total bilirubin ≤ 2 × ULN. 5.Renal function: serum creatinine ≤ ULN. 6.Absence of uncontrolled infection or severe psychiatric/psychological disorders. 7.Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2. 8.Signed informed consent. 9.Diagnosis of grade II acute GVHD as assessed by the modified Glucksberg grading criteria for acute GVHD. Exclusion Criteria: * 1.Absence of an allogeneic donor. 2.Pregnancy of either the donor or the recipient. 3.Presence of psychiatric disorders or other conditions that preclude compliance with the study protocol.